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Desloratadine and depression, a drug safety signal based on worldwide spontaneous reporting of side effects.

Author: BoerJeltje, EderveenEllen, GrundmarkBirgitta

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Desloratadine, a third-generation antihistamine, is claimed to cause fewer central nervous system (CNS) side effects than older antihistamines. However, symptoms like somnolence and hallucinations have been reported, suggesting that desloratadine can cross the blood-brain barrier.
Paper Details　
Original Abstract of the Article :
Desloratadine, a third-generation antihistamine, is claimed to cause fewer central nervous system (CNS) adverse drug reactions (ADRs) than antihistamines of the first- and second-generation. While literature is inconclusive regarding the possible CNS effects, symptoms like somnolence and hallucinati...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198223/

データ提供：米国国立医学図書館（NLM）

Desloratadine and Depression: A Drug Safety Signal Emerges

The world of [pharmacology] is often a desert of unknowns, where the effects of medications can sometimes be surprising. This study investigates a potential [drug safety signal] associated with [desloratadine], a widely used antihistamine. This is like discovering a hidden sandstorm in the desert, revealing unexpected and potentially harmful consequences.

Desloratadine and Depression: A Complex Relationship

While [desloratadine] is generally considered to be safe and effective, this study highlights the potential for [depression] to be a [side effect] of this medication. This finding is like uncovering a hidden spring in the desert, revealing a previously unknown aspect of the medication's impact on the body. The study is based on a worldwide spontaneous reporting system of [side effects], suggesting that this potential association might be broader than previously thought.

Implications for Antihistamine Use: Navigating the Sands of Drug Safety

This study emphasizes the importance of continuous monitoring and reporting of [drug safety signals], especially for commonly used medications like [desloratadine]. This is like establishing a network of watchtowers across the desert, ensuring vigilant observation and communication to detect potential dangers. Further research is needed to fully understand the potential relationship between [desloratadine] and [depression] and to determine the best course of action for patients taking this medication.

Dr. Camel's Conclusion

This study serves as a reminder that even seemingly safe medications can have unexpected side effects. It highlights the importance of open communication between patients and healthcare professionals and the need for ongoing vigilance in the world of [pharmacology]. This is like learning to navigate the unpredictable landscape of the desert, where every step can bring new challenges and opportunities.
Date :
  1. Date Completed 2018-12-20
  2. Date Revised 2018-12-20
Further Info :

Pubmed ID

30084285

DOI: Digital Object Identifier

PMC6198223

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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