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Meloxicam-desmopressin drug-drug interaction producing hyponatremia.
Author: BojdaniErmal, BuonocoreStefania, ChenAnderson, GurreraRonald, LiKevin J
Original Abstract of the Article :
BACKGROUND: People with schizophrenia and medical comorbidities are often on multiple medications to manage their symptoms. Herein we present a case of drug-drug interaction (meloxicam and desmopressin), in a patient also on clozapine, that ultimately resulted in hyponatremia and seizure. METHODS: ...See full text at original site
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引用元:
https://doi.org/10.1016/j.psychres.2019.05.009
データ提供:米国国立医学図書館(NLM)
Meloxicam and Desmopressin: A Tale of Unexpected Interactions
In the realm of [pharmacology], drug interactions can sometimes be unpredictable, like a shifting desert landscape where unexpected paths appear. This study delves into a case report involving a patient with schizophrenia who experienced hyponatremia, a dangerous condition characterized by low sodium levels in the blood, after taking meloxicam and desmopressin. The researchers meticulously explored the potential interactions between these medications, uncovering a complex interplay that resulted in a medical emergency. Their findings highlight the importance of careful medication monitoring and the need to be mindful of potential drug interactions, even in seemingly unrelated medications.
Meloxicam: A Hidden Culprit
The study concluded that meloxicam, an NSAID (nonsteroidal anti-inflammatory drug), enhanced the hyponatremia-inducing effect of desmopressin, a medication used to treat certain types of diabetes insipidus. It's like a hidden sandstorm that can disrupt the delicate balance of the body's systems. The researchers provide a detailed analysis of the case, meticulously evaluating the patient's medications and medical history to pinpoint the culprit. Their findings underscore the importance of considering all medications, even seemingly unrelated ones, when assessing potential drug interactions.
Navigating Medications: A Balancing Act
This case report serves as a cautionary tale for healthcare professionals and patients alike. It's a reminder that medications, like desert travelers navigating a complex landscape, can interact in unexpected ways. The researchers emphasize the need for careful monitoring of serum sodium levels in patients taking desmopressin and for avoiding NSAIDs in individuals with schizophrenia who are also prescribed vasopressin or desmopressin. By adopting a proactive approach to medication management, we can minimize the risk of adverse drug interactions and ensure patient safety.
Dr.Camel's Conclusion
This case report is a compelling reminder of the complex nature of drug interactions. It's like uncovering a hidden oasis, revealing a previously unknown aspect of the desert of pharmaceutical knowledge. The study underscores the importance of careful medication monitoring and highlights the potential for unforeseen consequences when combining medications, emphasizing the need for vigilant vigilance in this area.
Date :
- Date Completed 2020-03-31
- Date Revised 2020-03-31
Further Info :
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English
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