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Peripheral Opioid Receptor Antagonists for Opioid-Induced Constipation: A Primer on Pharmacokinetic Variabilities with a Focus on Drug Interactions.

Author: FudinJeffrey, GudinJeffrey

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

PAMORAs (peripherally acting µ-receptor antagonists) are used to treat opioid-induced constipation (OIC). Each PAMORA has unique pharmacokinetic properties that may be impacted by coadministered drugs or food. This review focuses on important metabolic and pharmacokinetic principals that are pertinent to drug interactions involving µ-opioid receptor antagonists prescribed for OIC.
Paper Details　
Original Abstract of the Article :
Opioid analgesics remain a treatment option for refractory acute and chronic pain, despite their potential risk for abuse and adverse events (AEs). Opioids are associated with several common AEs, but the most bothersome is opioid-induced constipation (OIC). OIC is often overlooked but has the potent...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049282/

データ提供：米国国立医学図書館（NLM）

Opioid-Induced Constipation: A Desert Oasis for Relief

Opioid analgesics, while providing relief for pain, often come with a side effect that can feel like a desert wasteland: opioid-induced constipation (OIC). OIC can severely impact quality of life, but thankfully, a class of drugs known as peripherally acting µ-receptor antagonists (PAMORAs) has emerged to combat this desert drought. PAMORAs work by targeting receptors in the gastrointestinal tract, without affecting the pain-relieving effects of opioids.

PAMORAs: A Guide Through the Intricacies of Opioid-Induced Constipation

This review delves into the unique pharmacokinetic properties of PAMORAs, highlighting their potential interactions with other medications. The authors emphasize the importance of understanding these interactions, as they can significantly affect the efficacy and safety of PAMORAs. This information is crucial for clinicians, who can then navigate the complex landscape of drug interactions with greater precision.

Navigating the Desert of Drug Interactions

The review provides valuable insights for clinicians to tailor treatment plans and minimize the risk of adverse events. By understanding the pharmacokinetic nuances of PAMORAs, clinicians can choose the best treatment for each patient and ensure a smooth journey through the desert of drug interactions.

Dr.Camel's Conclusion

The desert of opioid-induced constipation can be a harsh and unforgiving place, but with the help of PAMORAs and a thorough understanding of their pharmacokinetic properties, we can create a more comfortable oasis for those who need pain relief. This review is a valuable guide for navigating the complexities of drug interactions and ensuring that patients receive the best possible care.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-09-28
Further Info :

Pubmed ID

32158255

DOI: Digital Object Identifier

PMC7049282

SNS
PICO Info
in preparation
Languages

English

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