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Water/pH dual responsive in situ calcium supplement collaborates simvastatin for osteoblast promotion mediated osteoporosis therapy via oral medication.

Author: HuFuqiang, LvJianghong, SongYanqing, TaoShan, WangCheng, YuFangying, YuanHong, ZhaoRui, ZhouWentao

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study presents a novel drug delivery system (TMA/Sim) for treating osteoporosis. TMA is a tetracycline-modified and monostearin-coated amorphous calcium carbonate platform designed for oral bone-targeted delivery and in situ calcium supplementation. By loading simvastatin (Sim) into TMA, the system synergistically activates the BMPs-Smad pathway, promoting osteoblast activity. The TMA/Sim system demonstrated high accessibility and oral availability with targeted drug delivery to bone tissue, effectively reversing osteoporosis under low calcium dosage.
Paper Details　
Original Abstract of the Article :
Calcium supplement is the most commonly adopted treatment for osteoporosis but usually requires high dose and frequency. The modality of calcium supplement is therefore overlooked by current nanomedicine-based osteoporosis therapies without proper oral formulations. Herein, we proposed a tetracyclin...See full text at original site
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引用元：
https://doi.org/10.1016/j.jconrel.2020.11.059

データ提供：米国国立医学図書館（NLM）

Water/pH Dual Responsive In Situ Calcium Supplement for Osteoporosis: A Novel Approach

Bone health is like a strong camel's spine, providing support and structure. This study addresses the challenge of osteoporosis, a condition where bones become weak and brittle, It introduces a novel approach using a water/pH dual-responsive in situ calcium supplement. Think of it like a camel carrying a load of precious minerals that release exactly where and when they are needed.

The researchers developed a platform called TMA, which uses a modified amorphous calcium carbonate (ACC) that is released in the body's bone environment. It's like a camel with a special pack that opens automatically when it reaches a specific destination. The study also incorporated simvastatin into the platform to promote bone regeneration, like a camel carrying both nutrients and tools for building stronger bones.

TMA/Sim: A Synergistic Approach to Osteoporosis

TMA/Sim, with its dual-responsive calcium supplement and targeted drug delivery, has shown potential in promoting bone regeneration and mitigating osteoporosis. This combination could offer a more effective and targeted approach to managing osteoporosis. Like a camel equipped with the right resources and a clear path, TMA/Sim could help strengthen bones and improve overall health.

Bone Health and Your Lifestyle

Maintaining strong bones is essential for overall health. Make sure to get enough calcium and vitamin D through diet and supplements, and consider engaging in weight-bearing exercises. It's like giving your camel the right fuel and exercise to keep it strong and resilient.

Dr. Camel's Conclusion

This study presents a promising new approach to treating osteoporosis. TMA/Sim offers a combination of targeted calcium delivery and bone-building properties, potentially leading to more effective and personalized treatment. Like a camel well-prepared for a long journey, this innovative approach could help strengthen bones and support overall health.

Date :
  1. Date Completed 2021-07-05
  2. Date Revised 2021-07-05
Further Info :

Pubmed ID

33279604

DOI: Digital Object Identifier

10.1016/j.jconrel.2020.11.059

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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