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A Review of Novel Agents and Clinical Considerations in Patients With ATTR Cardiac Amyloidosis.
Author: BenbrahimMeissane, HughesDavid, NormanKelsey, SanchorawalaVaishali, SiddiqiOmar K
Original Abstract of the Article :
Transthyretin (ATTR) amyloidosis is a multisystem disease caused by organ deposition of amyloid fibrils derived from the misfolded transthyretin (TTR) protein. The purpose of this article is to provide an overview of current treatment regimens and summarize important considerations for each agent. A...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/33657048
データ提供:米国国立医学図書館(NLM)
Novel Agents and Clinical Considerations in ATTR Cardiac Amyloidosis
ATTR amyloidosis, a rare and complex disease, involves the deposition of misfolded transthyretin (TTR) protein in various organs. This research provides an overview of current treatment regimens for ATTR cardiac amyloidosis and summarizes important considerations for each agent. The authors review available therapies such as tafamidis, diflunisal, patisiran, and inotersen, as well as investigational therapies like AG10 and PRX004. This comprehensive review provides valuable information for healthcare professionals and patients seeking to understand the evolving landscape of ATTR amyloidosis treatment.
Emerging Therapies Offer Hope for ATTR Cardiac Amyloidosis
The review highlights the emergence of several promising therapies for ATTR cardiac amyloidosis. These therapies include TTR stabilizers, antifibril agents, and gene silencers, offering different mechanisms of action to target the underlying disease process. The development of these novel agents represents a significant step towards improving treatment options for individuals with ATTR amyloidosis.
Navigating the Treatment of ATTR Amyloidosis
This review underscores the importance of understanding the different types of ATTR amyloidosis and the specific treatment considerations for each. The information provided offers valuable guidance for healthcare professionals in selecting appropriate therapies based on patient characteristics, disease subtype, and presence of cardiac or neurological manifestations.
Dr.Camel's Conclusion
Imagine a camel traversing a vast desert, seeking a cure for a rare and debilitating disease. This research is like a caravan of knowledge, bringing together diverse treatment options for ATTR cardiac amyloidosis. From TTR stabilizers to gene silencers, the journey towards effective therapies continues, offering hope for individuals facing this complex disease.
Date :
- Date Completed 2021-12-08
- Date Revised 2023-09-11
Further Info :
Related Literature
English
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