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Terbinafine Hydrochloride Combined With Itraconazole for Fungal Skin Diseases: A Randomized Controlled Trial.

Author: ChenCanhua, LaiHongtao, LiaoWanqing, LiuShi, ZhangDongxing

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Combined treatment with terbinafine and itraconazole achieved better therapeutic effects in patients with fungal skin diseases compared to monotherapy. The combination group had significantly decreased symptom scores, a higher cure rate, and shorter cure time. No adverse events or relapses were reported during follow-up.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Terbinafine and itraconazole are the common antifungal drugs in clinic. In vitro experiments proved that terbinafine combined with itraconazole achieves better antifungal effects. However, clinical study addressing this issue was still scarce. STUDY QUESTION: Terbinafine combined with i...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/33687025

データ提供：米国国立医学図書館（NLM）

A Powerful Combination: Terbinafine and Itraconazole for Fungal Skin Diseases

The field of dermatology is constantly seeking effective treatments for fungal skin infections. This study investigates the therapeutic efficacy of combining terbinafine and itraconazole, two common antifungal drugs, for treating fungal skin diseases. The researchers conducted a randomized controlled trial with 152 patients, comparing the combined treatment with monotherapy using either terbinafine or itraconazole. The study's findings demonstrate that combining terbinafine and itraconazole achieves better therapeutic effects in fungal skin diseases compared to monotherapy.

Synergistic Antifungal Effects

The study's results highlight the synergistic antifungal effects of combining terbinafine and itraconazole. The combined treatment resulted in significantly lower symptom scores, a higher cure rate, and a shorter cure time compared to monotherapy. The combined treatment also demonstrated a 100% cure rate for patients with fungal skin diseases, with no reported adverse events or relapse of disease during follow-up.

Optimizing Fungal Skin Disease Treatment

This research provides valuable evidence for the efficacy of combining terbinafine and itraconazole for treating fungal skin diseases. The study's findings suggest that this combination treatment may offer a more effective and efficient approach to managing these infections, leading to faster recovery and improved patient outcomes. Healthcare providers should consider this combined treatment option for patients with fungal skin diseases.

Dr.Camel's Conclusion

This study's exploration of the combination treatment of terbinafine and itraconazole for fungal skin diseases offers a promising approach to managing these infections. The findings demonstrate the potential of this combined treatment to achieve better therapeutic outcomes, faster recovery, and improved patient satisfaction. Just as camels adapt to the diverse challenges of the desert, healthcare professionals must continually seek new and innovative approaches to treating fungal skin diseases, ensuring the best possible outcomes for their patients.

Date :
  1. Date Completed 2021-09-29
  2. Date Revised 2022-04-21
Further Info :

Pubmed ID

33687025

DOI: Digital Object Identifier

00045391-202104000-00002

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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