Paper Details

  1. Home
  2. Paper Details

Longitudinal Evaluation of the Effect of Tricyclic Antidepressants and Neuroleptics on the Course of Huntington's Disease-Data from a Real World Cohort.

Author: AchenbachJannis, FaissnerSimon, SaftCarsten

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tricyclic antidepressants and neuroleptics did not show a neuroprotective effect on disease progression in Huntington's disease (HD) patients. The study found no differences in motoric, functional, and cognitive disease progression between groups treated with these medications and a control group. However, some treatment groups showed higher baseline motor scores, more dystonia, and lower functional and cognitive performance at baseline, potentially caused by side effects or selection bias.
Paper Details　
Original Abstract of the Article :
<b>Background:</b> Reducing the progress of neurodegeneration is a key goal in Huntington&#180;s disease (HD). A previously performed systematic screening for medications with neuroprotective features identified tricyclic antidepressants and neuroleptics as neuroprotective and mitochondrioprotectiv...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064332/

データ提供：米国国立医学図書館（NLM）

Examining the Role of Tricyclic Antidepressants and Neuroleptics in Huntington's Disease

This study analyzed a large real-world cohort of Huntington's disease (HD) patients to investigate the potential effects of tricyclic antidepressants and neuroleptics on disease progression. The researchers sought to determine if these medications might offer neuroprotective benefits.

Hunting for Neuroprotection in the Desert of HD

The study's findings did not support the hypothesis that tricyclic antidepressants and neuroleptics have a neuroprotective effect on HD progression. This research journey was like searching for a rare oasis in the vast and unforgiving desert of HD. While the study did not find conclusive evidence of neuroprotection, it highlights the ongoing need for research into effective treatments for this devastating disease.

Navigating the Challenges of Huntington's Disease

The study underscores the importance of continued research into potential treatments for HD, a complex and debilitating disease. This research journey reminds us that even in the face of challenging medical conditions, scientists must continue to explore new possibilities and approaches.

Dr.Camel's Conclusion

This study reinforces the importance of pursuing research into potential treatments for HD, a disease that affects both individuals and their families. Even if the initial results are not conclusive, it is essential to persevere in our search for solutions, like a persistent camel traversing the boundless desert, seeking the oasis of hope.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

33805940

DOI: Digital Object Identifier

PMC8064332

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.