Observational study on the effectiveness and safety of multiple regimens of triclabendazole in human fascioliasis after failure to standard-of-care regimens.

Author: CanalesMarco, MacoVicente, MarcosLuis A, TerashimaAngélica

Paper Details 
Original Abstract of the Article :
Triclabendazole (TCBZ) is the recommended anthelmintic against Fasciola hepatica at a dose of 10 mg/kg body weight administered as a single or double dose. However, treatment failures to TCBZ standard-of-care (SOC) doses have been reported in humans. The aim of this study was to describe the effecti...See full text at original site
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引用元:
https://doi.org/10.1016/j.jgar.2021.03.023

データ提供:米国国立医学図書館(NLM)

Fascioliasis: A Challenge in the Desert of Parasitic Infections

The realm of [parasitology] is a vast and often challenging landscape, where parasites can pose significant threats to human health. This research focuses on [fascioliasis], a parasitic infection caused by Fasciola hepatica. The authors explore the effectiveness and safety of various [triclabendazole (TCBZ)] regimens in treating fascioliasis, particularly in cases where standard-of-care (SOC) doses have failed.

Navigating the Desert of Treatment Failure

This study reveals that treatment failure to standard-of-care TCBZ doses is a real concern in fascioliasis. It's like encountering a treacherous sandstorm that hinders your progress. The authors investigate the efficacy and tolerability of alternative TCBZ regimens in patients who have failed the SOC regimen.

A Multifaceted Approach: Combating Parasitic Infections

This research highlights the need for individualized treatment approaches in fascioliasis, taking into account factors such as previous treatment experience, parasite resistance, and patient tolerance. It's a reminder that every journey in the desert of parasitic infections requires a tailored strategy for success.

Dr. Camel's Conclusion

This study emphasizes the importance of continued research and clinical experience in managing fascioliasis, particularly in cases of treatment failure. It highlights the need for flexible and adaptive treatment strategies to address the complexities of parasitic infections.

Date :
  1. Date Completed 2021-07-01
  2. Date Revised 2021-07-01
Further Info :

Pubmed ID

33862276

DOI: Digital Object Identifier

10.1016/j.jgar.2021.03.023

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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