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JAK-inhibitors in dermatology - small molecules, big impact? Overview of the mechanism of action, previous study results and potential adverse effects.

Author: KleinBenjamin, SimonJan C, TreudlerRegina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

JAK inhibitors are promising therapeutic agents for chronic inflammatory skin diseases. They act by targeting the JAK-STAT pathway and have shown impressive effects in atopic dermatitis, psoriasis, and other skin conditions. This review discusses the active principles of JAK inhibitors, their effectiveness in different skin diseases, and potential side effects.
Paper Details　
Original Abstract of the Article :
Numerous chronic inflammatory skin diseases are associated with the release of proinflammatory cytokines, which act via the intracellular JAK-STAT pathway. JAK inhibitors represent a promising, targeted therapeutic approach for cutaneous diseases. Impressive effects have been achieved with these age...See full text at original site
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引用元：
https://doi.org/10.1111/ddg.14668

データ提供：米国国立医学図書館（NLM）

JAK Inhibitors: A Promising Therapeutic Approach for Inflammatory Skin Diseases

This review article explores the potential of JAK inhibitors as targeted therapies for a range of chronic inflammatory skin diseases. The researchers discuss the mechanism of action of these small molecules, review clinical trial results, and highlight potential adverse effects.

Targeting the JAK-STAT Pathway in Skin Diseases

The review highlights the role of the JAK-STAT pathway in mediating proinflammatory cytokine signaling in various skin diseases. JAK inhibitors offer a promising therapeutic approach by specifically targeting this pathway, potentially reducing inflammation and improving skin symptoms.

New Therapeutic Options for Skin Diseases

The review suggests that JAK inhibitors, such as Baricitinib, Upadacitinib, and Abrocitinib, represent a significant advancement in the treatment of moderate to severe atopic dermatitis and other inflammatory skin diseases. The research suggests that these agents may offer a more targeted and effective approach to managing these conditions.

Dr.Camel's Conclusion

This review provides a comprehensive overview of the emerging field of JAK inhibitors in dermatology. The researchers highlight the potential of these small molecules to revolutionize the treatment of inflammatory skin diseases by offering a more targeted and effective approach to reducing inflammation and improving skin symptoms. However, the review emphasizes the importance of careful monitoring for potential adverse effects and further research to optimize the use of these agents.

Date :
  1. Date Completed 2022-02-04
  2. Date Revised 2022-02-04
Further Info :

Pubmed ID

34962052

DOI: Digital Object Identifier

10.1111/ddg.14668

SNS
PICO Info
in preparation
Languages

English

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