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Bronchodilator and side effects of different modes of administration of metaproterenol: inhaled, oral, and in combination.

Author: EmirgilC, MaguireG P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Inhaled and oral metaproterenol were compared in 20 patients with asthma. The combination of inhaled and oral metaproterenol resulted in greater bronchodilation than either route alone. Inhaled metaproterenol had no significant side effects, while oral metaproterenol was associated with a small increase in pulse rate and blood pressure and unpleasant sensations such as tremor and palpitation.
Paper Details　
Original Abstract of the Article :
Twenty subjects with clinically stable asthma were treated in double-blind crossover manner with inhaled and oral metaproterenol, alone and in combination. The combination of inhaled and oral metaproterenol resulted in a greater degree of bronchodilation than either inhaled or oral alone. Inhaled me...See full text at original site
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引用元：
https://doi.org/10.1097/00000441-198603000-00005

データ提供：米国国立医学図書館（NLM）

Metaproterenol: A Multifaceted Approach to Asthma Management

This study, like a careful exploration of a vast desert landscape, investigates the effectiveness of different modes of administration for metaproterenol, a bronchodilator used to treat asthma. The researchers, like skilled desert guides, compared inhaled and oral metaproterenol, both individually and in combination, seeking to optimize treatment strategies for asthma patients.

A Symphony of Relief: Metaproterenol's Impact on Asthma

The study found that the combination of inhaled and oral metaproterenol provided greater bronchodilation compared to either route alone, suggesting that a multi-pronged approach, like the multiple paths through a desert oasis, can offer improved effectiveness. The researchers observed that inhaled metaproterenol was well tolerated, while oral metaproterenol, like a desert journey with a few unexpected bumps, was associated with some side effects, such as increased heart rate.

A Path to Better Breathing: Optimizing Metaproterenol Therapy

The findings highlight the importance of individualizing treatment strategies for asthma, considering factors such as the patient's age and response to different modes of administration. The researchers, like skilled desert healers, emphasize the need to find the right path to optimal relief, ensuring the most effective and well-tolerated treatment for each individual.

Dr. Camel's Conclusion

This study offers valuable insights into the effectiveness of different metaproterenol delivery methods for asthma management. The researchers, like knowledgeable desert physicians, have provided a roadmap for optimizing asthma treatment, ensuring a more comfortable and effective journey for patients navigating the challenges of this chronic condition.
Date :
  1. Date Completed 1986-04-22
  2. Date Revised 2019-07-16
Further Info :

Pubmed ID

3513564

DOI: Digital Object Identifier

10.1097/00000441-198603000-00005

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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