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Captopril and opiate antagonism in essential hypertension.

Author: AjayiA A, ReidJ L, RubinP C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Naloxone did not modify the circulatory effects of captopril in patients who had been taking captopril for 2-25 months. This finding suggests that the antihypertensive effects of captopril are not significantly mediated by endogenous opioids in the long term.
Paper Details　
Original Abstract of the Article :
Six patients maintained on 50-100 mg captopril, for 2-25 months, were administered captopril 50 mg orally, together with either naloxone or 0.9% saline vehicle (placebo) given intravenously, in a double-blind crossover study. Naloxone did not appear to modify the circulatory effects of captopril in ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2125.1986.tb02840.x

データ提供：米国国立医学図書館（NLM）

Captopril and Opiate Antagonism in Essential Hypertension

This study delves into the intriguing interaction between captopril, an antihypertensive drug, and opioid systems in the body. It explores the potential role of endogenous opioids in mediating the effects of captopril on blood pressure, offering insights into the complex interplay between these systems.

The study investigates the effect of naloxone, an opioid antagonist, on the circulatory effects of captopril in patients with essential hypertension. The results indicate that naloxone did not significantly modify the effects of captopril on blood pressure, suggesting that endogenous opioids may not play a major role in the chronic antihypertensive effects of captopril.

The study also highlights a potential difference in the mechanisms involved in the early and long-term effects of captopril. The results suggest that the initial short-term reduction in blood pressure may be mediated by different mechanisms than those responsible for the long-term effects, indicating the complexity of captopril's actions on the cardiovascular system.

Understanding the Complexities of Blood Pressure Regulation

The study's findings contribute to our understanding of the complex mechanisms involved in regulating blood pressure. This research highlights the interplay between various systems, including the cardiovascular system and the opioid system, and underscores the need for a multifaceted approach to managing hypertension.

The Importance of Personalized Treatment

The study's findings suggest that individual responses to antihypertensive medications can vary depending on factors such as the involvement of endogenous opioid systems. This emphasizes the importance of personalized treatment approaches to hypertension, tailoring medication and management strategies to meet the unique needs of individual patients.

Dr. Camel's Conclusion

This research provides valuable insights into the complex relationship between captopril, opioid systems, and blood pressure regulation. It highlights the need for a nuanced understanding of these interactions to develop more effective and individualized treatments for hypertension.

Date :
  1. Date Completed 1986-07-25
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

3521691

DOI: Digital Object Identifier

10.1111/j.1365-2125.1986.tb02840.x

SNS
PICO Info
in preparation
Languages

English

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