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The Frey syndrome: a review and double blind evaluation of the topical use of a new anticholinergic agent.

Author: HaysL L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Glycopyrrolate was found to be effective in controlling gustatory sweating in patients with Frey syndrome. In a double-blind clinical trial, topical glycopyrrolate at concentrations of 0.5% and 1.0% provided complete control of gustatory sweating for at least several days after a single application.
Paper Details　
Original Abstract of the Article :
The symptom complex of localized facial gustatory sweating and flushing during mastication (The Frey syndrome) is a common sequela of parotidectomy with facial nerve dissection. A thorough review of the literature concerning the Frey syndrome is reported. The procedure of tympanic neurectomy has rec...See full text at original site
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引用元：
https://doi.org/10.1288/00005537-197811000-00010

データ提供：米国国立医学図書館（NLM）

Frey Syndrome: A Review and Double-Blind Evaluation of Glycopyrrolate

The Frey syndrome, characterized by facial sweating and flushing during chewing, is a common complication of parotidectomy, surgery to remove the parotid gland. This study reviews the literature on Frey syndrome and evaluates the effectiveness of topical glycopyrrolate as a treatment for this condition.

Treating Gustatory Sweating with Topical Glycopyrrolate

This study found that topical glycopyrrolate, an anticholinergic agent, was effective in controlling gustatory sweating in patients with Frey syndrome. In a double-blind clinical trial, topical glycopyrrolate was found to be as effective as scopolamine, a commonly used anticholinergic agent for this condition, but with fewer side effects. These findings suggest that topical glycopyrrolate could be a valuable alternative to surgical interventions for treating Frey syndrome.

Health Implications and Lifestyle Considerations

Frey syndrome can be a distressing condition that affects quality of life. This study highlights the potential of topical glycopyrrolate as a safe and effective treatment option. It is essential to discuss treatment options with your healthcare provider to determine the best course of action for managing Frey syndrome.

Dr.Camel's Conclusion

This study offers a promising non-surgical approach to treating Frey syndrome. It suggests that topical glycopyrrolate could be a valuable alternative to existing treatment options, providing relief from gustatory sweating and improving the quality of life for patients with this condition.
Date :
  1. Date Completed 1979-01-24
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

362094

DOI: Digital Object Identifier

10.1288/00005537-197811000-00010

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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