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Fluoroquinolone Derivatives in the Treatment of <i>Mycobacterium tuberculosis</i> Infection.

Author: AnesElsa, ConstantinoLuís, FranciscoAna Paula, MadureiraAna Margarida, PaisJoão Pedro, PiresDavid, PolicarpoMargarida, TestaBernard

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the use of esters as prodrugs of the fluoroquinolones levofloxacin and ciprofloxacin, to improve their delivery to mycobacterial cells. While the derivatives showed reduced antitubercular activity, they retained activity against fluoroquinolone-resistant bacteria, suggesting a different mode of action. Further investigation is needed to determine the potential of these compounds for treating resistant strains.
Paper Details　
Original Abstract of the Article :
Tuberculosis (TB) is currently one of the leading causes of death due to infective agents, and the growing rate of multidrug-resistant tuberculosis (MDR TB) cases poses an emergent public health threat. Fluoroquinolones are commonly used in the treatment of both MDR TB and drug-sensitive tuberculosi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609866/

データ提供：米国国立医学図書館（NLM）

Fluoroquinolone Derivatives: Potential Weapons Against Mycobacterium tuberculosis

Tuberculosis (TB), a deadly infectious disease, poses a significant global health threat, particularly with the emergence of multidrug-resistant strains. This research explores the potential of fluoroquinolone derivatives as a weapon against Mycobacterium tuberculosis, the bacteria responsible for TB.

Developing New Therapies for Multidrug-Resistant TB

The researchers have developed ester prodrugs of fluoroquinolones, levofloxacin and ciprofloxacin, with long-chain fatty alcohols. The aim is to create compounds with improved lipophilicity, enabling them to effectively target Mycobacterium tuberculosis cells.

Fluoroquinolone Derivatives: A Promising Avenue for TB Treatment

While the synthesized derivatives showed reduced antitubercular activity against Mycobacterium tuberculosis, they exhibited bioactivity against other fluoroquinolone-resistant bacteria. This suggests a different mode of action and opens a new avenue for research and development of novel anti-TB agents.

Dr.Camel's Conclusion

This research delves into the potential of fluoroquinolone derivatives as a new weapon against Mycobacterium tuberculosis. The findings suggest a promising avenue for developing new therapies, particularly against multidrug-resistant strains, offering hope for combating this deadly infectious disease.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-10-30
Further Info :

Pubmed ID

36297325

DOI: Digital Object Identifier

PMC9609866

SNS
PICO Info
in preparation
Languages

English

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