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Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity.

Author: BunickChristopher G, DamianiGiovanni, Del RossoJames Q, GradaAyman, HarperJulie, MooreAngela Y, ObagiSabine, SalemRaidah J, ShawKatharina, Stein GoldLinda, TanakaS Ken

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compared the brain-penetrative and lipophilic attributes of sarecycline, a third-generation tetracycline, to minocycline. Unlike minocycline, sarecycline was not detected in brain samples, suggesting reduced blood-brain penetrance and a lower lipophilicity profile. These factors may explain the low rates of vestibular-related adverse events observed in clinical trials.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Vestibular side effects such as dizziness and vertigo can be a limitation for some antibiotics commonly used to treat acne, rosacea, and other dermatology indications. OBJECTIVE: Unlike minocycline, which is a second-generation tetracycline, sarecycline, a narrow-spectrum third-generati...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9773825/

データ提供：米国国立医学図書館（NLM）

Sarecycline: A New Era in Acne Treatment

Acne vulgaris is a common skin condition that can be effectively treated with antibiotics. This research focuses on sarecycline, a new antibiotic, and compares its brain penetration and lipophilicity to minocycline, another common acne treatment.

A Targeted Approach to Acne Treatment

The study found that sarecycline demonstrated significantly lower brain penetration compared to minocycline, indicating a reduced risk of vestibular side effects, such as dizziness and vertigo. This finding highlights the potential of sarecycline as a safer and more tolerable treatment option for acne.

Minimizing Side Effects, Maximizing Benefits

This research suggests that sarecycline might offer a more targeted and less disruptive approach to acne treatment. By minimizing the risk of vestibular side effects, sarecycline could potentially improve the quality of life for patients seeking effective acne treatment.

Dr.Camel's Conclusion

This research sheds light on the potential of sarecycline as a safer and more targeted treatment option for acne vulgaris. Its reduced brain penetration compared to minocycline suggests a lower risk of vestibular side effects, potentially leading to a better patient experience. This promising development could offer a new era in acne treatment, providing a more tolerable and effective solution for individuals seeking relief from this common skin condition.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-12-27
Further Info :

Pubmed ID

36569144

DOI: Digital Object Identifier

PMC9773825

SNS
PICO Info
in preparation
Languages

English

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