Side Effects of sarecycline: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Key Research Findings

Sarecycline is a tetracycline-derived oral antibiotic specifically designed for acne and approved by the FDA in 2018 for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris (AV) in patients 9 years of age and older. 6 Sarecycline has the potential to yield fewer side effects than other commonly used broad-spectrum tetracyclines, including minocycline and doxycycline. 6 The narrower spectrum of antibacterial activity of sarecycline, which specifically targets C. acnes and some Gram-positive bacteria with little or no activity against Gram-negative bacteria, suggests not only the potential for reduced emergence of antibiotic-resistant bacterial strains but also less disruption of the human gut microflora. 6

Reasons for Side Effects

Sarecycline is a type of tetracycline antibiotic. Tetracycline antibiotics work by inhibiting protein synthesis in bacteria. However, they can also affect human cells, which can lead to side effects. 6 Sarecycline is designed to have fewer side effects than traditional tetracycline antibiotics, but side effects are still possible. 6

Common Side Effects

Nasopharyngitis

The most common side effect of sarecycline is nasopharyngitis. 7 Nasopharyngitis is an inflammation of the nose and throat, which can resemble the symptoms of a cold. 7

Upper Respiratory Tract Infection

Upper respiratory tract infection is another common side effect of sarecycline. 7 Upper respiratory tract infection is an inflammation of the nose, throat, ears, and sinuses. 7

Headache

Headaches are also a common side effect of sarecycline. 7

Nausea

Nausea is a common side effect of sarecycline. 7

Dizziness

Dizziness has been reported as a side effect of sarecycline. 7 Sarecycline has been shown to have a lower risk of dizziness compared to traditional tetracycline antibiotics. 2

Sunburn

Sunburn has been reported as a side effect of sarecycline. 7 Sarecycline has been shown to have a lower risk of sunburn compared to traditional tetracycline antibiotics. 7

Side Effect Management

Nasopharyngitis, Upper Respiratory Tract Infection

If you experience severe symptoms of nasopharyngitis or an upper respiratory tract infection, consult a doctor. 7 Over-the-counter cold medications may help relieve symptoms. 7

Headache

If you have a severe headache, consult a doctor. 7 Over-the-counter pain relievers may help relieve symptoms. 7

Nausea

If you experience nausea, try eating small meals more frequently, eating bland foods, or making other dietary adjustments. 7 Over-the-counter anti-nausea medications may help relieve symptoms. 7

Dizziness

If you feel dizzy, avoid driving or operating machinery. 7 Consult a doctor. 7

Sunburn

If you are prone to sunburn, apply sunscreen and avoid prolonged sun exposure. 7 Consult a doctor. 7

Comparison of Studies

Similarities

Multiple studies have shown that sarecycline is effective in treating acne. 6 、 5 、 8 Studies have also shown that sarecycline has fewer side effects compared to traditional tetracycline antibiotics. 6 、 7

Differences

The effects and side effects of sarecycline may vary depending on the study. 6 、 5 、 8 This can be attributed to variations in the age of study participants, severity of acne, and research methodologies. 6 、 5 、 8

Implications for Real-World Application

Sarecycline is an effective medication for acne, but it can cause side effects. 6 Consult with a doctor before using sarecycline to understand the risks of side effects. 6

Limitations of Current Research

Research on sarecycline is still in its early stages. 6 Further research is needed to investigate the long-term effects of sarecycline and its effectiveness across different racial and ethnic groups. 6

Future Directions for Research

Studies are needed to investigate the long-term effects of sarecycline and its effectiveness across different racial and ethnic groups. 6 Research is also needed to investigate the efficacy of combination therapies involving sarecycline and other acne treatments. 6

Conclusion

Sarecycline is a new type of tetracycline antibiotic that is effective in treating acne. 6 、 5 、 8 Sarecycline may have fewer side effects compared to other common tetracycline antibiotics. 6 However, sarecycline can still cause side effects. 6 Consult with a doctor before using sarecycline to understand the risks of side effects. 6

Literature analysis of 8 papers
Positive Content
8
Neutral Content
0
Negative Content
0
Article Type
2
0
0
2
7
1.

Dasatinib-Associated Acneiform Eruption Successfully Treated With Sarecycline in a Patient With Chronic Myeloid Leukemia.

Author: PoplauskyDina, YoungJade N, DubinDanielle P, TremblayDouglas, GulatiNicholas

Acneiform eruption treatment

A case of a patient with chronic myeloid leukemia (CML) who developed an acneiform eruption after taking dasatinib is presented. The eruption was effectively treated with sarecycline, a narrow-spectrum tetracycline. Sarecycline is a potentially safer alternative to doxycycline, especially for long-term use.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

3.

Novel and emerging treatment options for acne vulgaris

Author: AuffretNicole, ClaudelJean Paul, LecciaMarie-Thérèse, BallangerFabienne, DrenoBrigitte

Improved acne treatment

This review provides an update on the latest advances in acne treatment, including new formulations and emerging therapies. The review covers novel treatments like Clascosterone, Trifarotene, and Sarecy-cline, as well as improved formulations of existing compounds like minocycline and tretinoin. The emerging therapies target different aspects of acne pathogenesis, including sebaceous gland activity, inflammation, and the skin microbiome.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Oral Sarecycline for Treatment of Papulopustular Rosacea: Results of a Pilot Study of Effectiveness and Safety.

Author: RossoJames Q, DraelosZoe Diana, EffronCheryl, KircikLeon H

Effective for rosacea
Reduced risk of resistance
Well tolerated

Cutaneous rosacea is a common inflammatory skin disorder. This review discusses the potential benefits of oral sarecycline for the treatment of rosacea. While sarecycline has shown effectiveness and safety for acne, further research is needed to confirm its efficacy and safety for rosacea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Sarecycline: A Review of Preclinical and Clinical Evidence.

Author: MooreAngela Yen, Del RossoJames, JohnsonJodi L, GradaAyman

Acne treatment
Less gut microbiota disruption
Reduced antibiotic resistance

This review summarizes the key preclinical and clinical evidence for sarecycline, a novel oral antibiotic specifically designed for acne. It explores its potential to yield fewer side effects compared to other tetracyclines and its potential for reduced antibiotic resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Once-Daily Oral Sarecycline 1.5 mg/kg/day Is Effective for Moderate to Severe Acne Vulgaris: Results from Two Identically Designed, Phase 3, Randomized, Double-Blind Clinical Trials.

Author: MooreAngela, GreenLawrence J, BruceSuzanne, SadickNeil, TschenEduardo, WerschlerPhilip, Cook-BoldenFran E, DhawanSunil S, ForshaDouglass, GoldMichael H, GuenthnerScott, KempersSteven E, KircikLeon H, ParishJennifer L, RendonMarta I, RichPhoebe, Stein-GoldLinda, TyringStephen K, WeissRobert A, NasirAdnan, SchmitzCarsten, BoodhooTerry I, KaoukhovAlexandre, BerkDavid R

Acne treatment
Side effects

Sarecycline, a narrow-spectrum tetracycline antibiotic, was safe, well tolerated, and effective in patients with moderate to severe acne.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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