Paper Details

  1. Home
  2. Paper Details

Intensive lipid-lowering therapy for early achievement of guideline-recommended LDL-cholesterol levels in patients with ST-elevation myocardial infarction ("Jena auf Ziel").

Author: GeilingJens-Arndt, HaxhikadrijaPellumb, LauerBernward, MakhmudovaUmidakhon, MalokuAurel, Möbius-WinklerSven, OttoSylvia, RömerRobert, SamadifarBeasat, SchulzeP Christian, WeingärtnerOliver

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The Jena auf Ziel (JaZ) study aims to achieve guideline-recommended LDL-C targets in all patients with ST-elevation myocardial infarction (STEMI) using a stepwise lipid-lowering therapy approach. Early combination therapy with atorvastatin and ezetimibe will be initiated on admission, followed by escalation with bempedoic acid and PCSK9 inhibitors during follow-up.
Paper Details　
Original Abstract of the Article :
Currently, less than 20% of patients at very high-risk achieve ESC/EAS dyslipidemia guideline-recommended LDL-C target levels in Europe. "Jena auf Ziel-JaZ" is a prospective cohort study in which early combination therapy with atorvastatin 80 mg and ezetimibe 10 mg was initiated on admission in pati...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449699/

データ提供：米国国立医学図書館（NLM）

Intensive Lipid-Lowering Therapy: A Beacon of Hope for STEMI Patients

This prospective cohort study investigates the effectiveness of intensive lipid-lowering therapy in patients with ST-elevation myocardial infarction (STEMI), emphasizing the importance of achieving guideline-recommended LDL-cholesterol target levels early in the treatment process. The researchers demonstrate the feasibility of escalating lipid-lowering therapy with a combination of statins, ezetimibe, bempedoic acid, and PCSK9 inhibitors to achieve desired LDL-C targets, highlighting the potential for improving cardiovascular outcomes in this high-risk population.

STEMI: Navigating the Stormy Seas of Cardiovascular Disease

This study underscores the importance of aggressive lipid management in patients with ST-elevation myocardial infarction (STEMI), a serious and potentially life-threatening condition. It's like navigating a stormy sea, where quick and decisive action is crucial for survival. The authors highlight the potential of intensive lipid-lowering therapy to improve cardiovascular outcomes in this high-risk population, offering a beacon of hope for patients facing this challenging diagnosis.

The Importance of Early Intervention

This study emphasizes the importance of early and aggressive intervention in managing cardiovascular disease. It's like recognizing that a storm in the desert can quickly escalate, requiring immediate action for survival. The authors demonstrate the effectiveness of intensive lipid-lowering therapy initiated early in the treatment process, underscoring the critical role of prompt and decisive care in optimizing outcomes for STEMI patients.

Dr.Camel's Conclusion

This study highlights the potential of intensive lipid-lowering therapy to improve cardiovascular outcomes in patients with ST-elevation myocardial infarction (STEMI). It's like finding a safe harbor in the midst of a stormy sea, offering hope for patients facing this challenging diagnosis. The authors emphasize the importance of achieving guideline-recommended LDL-cholesterol target levels early in the treatment process, highlighting the critical role of early intervention in optimizing patient outcomes.

Date :
  1. Date Completed 2023-08-25
  2. Date Revised 2023-08-28
Further Info :

Pubmed ID

36602598

DOI: Digital Object Identifier

PMC10449699

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.