Paper Details

  1. Home
  2. Paper Details

IFN-α induced systemic lupus erythematosus complicated with hemophagocytic lymphohistiocytosis: a case report and literature review.

Author: HuangKecheng, JiBai, LiuJie, NieDaan, TuWei, YangLiu, ZengZhipeng

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Hemophagocytic lymphohistiocytosis (HLH) is a severe and life-threatening inflammatory condition. This case study reports an unusual complication of HLH occurring during the treatment of drug-induced lupus erythematosus (DILE) in a 31-year-old male patient. The patient was successfully treated with a combination therapy.
Paper Details　
Original Abstract of the Article :
Hemophagocytic lymphohistiocytosis (HLH) is a severe and life-threatening hyperinflammatory condition characterized by excessive activation of macrophages and T cells and resulted in multi-organ dysfunction. HLH can be a primary disease or secondary to infections, malignancy, and some autoimmune dis...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436618/

データ提供：米国国立医学図書館（NLM）

A Rare Complication: IFN-α Induced Systemic Lupus Erythematosus Complicated with Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a serious and life-threatening inflammatory condition. This study reports a rare case of HLH occurring as a complication of drug-induced lupus erythematosus (DILE) in a patient receiving IFN-α therapy. The patient initially received IFN-α for the treatment of chronic hepatitis B but subsequently developed SLE and HLH. The authors emphasize the importance of recognizing potential autoimmune side effects of IFN-α therapy and maintaining vigilance for HLH in patients diagnosed with SLE.

The Importance of Monitoring Immune System Responses

This case report serves as a stark reminder of the complex interplay between medications and the immune system. While IFN-α therapy can be effective for certain conditions, it can also trigger autoimmune reactions like SLE and potentially lead to life-threatening complications like HLH. This case highlights the crucial need for careful monitoring of patients receiving IFN-α therapy to identify early signs of adverse events.

Navigating the Labyrinth of Autoimmune Diseases

Understanding the intricate workings of the immune system is essential in navigating autoimmune diseases. While medications can provide relief, it's important to be aware of their potential side effects and to work closely with healthcare professionals to identify and manage any complications that may arise. It's like navigating a vast and winding desert; careful observation and strategic planning are crucial to avoid potential pitfalls.

Dr. Camel's Conclusion

This research underscores the importance of careful monitoring and personalized approaches in treating complex medical conditions. It's like navigating a shifting desert landscape, requiring adaptability and a willingness to adjust course based on new insights. The authors' report serves as a valuable resource for healthcare professionals, emphasizing the need to remain vigilant and to consider the potential for unexpected complications when administering medications.

Date :
  1. Date Completed 2023-08-22
  2. Date Revised 2023-08-31
Further Info :

Pubmed ID

37600795

DOI: Digital Object Identifier

PMC10436618

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.