Paper Details

  1. Home
  2. Paper Details

A Prospective Longitudinal Study of the Effects of Eslicarbazepine Acetate Treatment on Bone Density and Metabolism in Patients with Focal-Onset Epilepsy.

Author: HirschMartin, ImmischIlka, KnakeSusanne, Schulze-BonhageAndreas

Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the potential adverse effects of eslicarbazepine acetate (ESL), a third-generation anti-seizure medication, on bone health. It aimed to determine whether ESL exposure for 12 months could affect bone mineral density (BMD) and bone turnover markers.
Paper Details　
Original Abstract of the Article :
Eslicarbazepine acetate (ESL) is a third-generation anti-seizure medication for patients with focal-onset epilepsy. There are known short-term impacts of classic enzyme-inducing drugs on bone health. For oxcarbazepine, which like ESL is a less potent inducer of cytochrome P450 (CYP450) than carbamaz...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667382/

データ提供：米国国立医学図書館（NLM）

Investigating the Effects of Eslicarbazepine Acetate on Bone Health: A Longitudinal Study

This study examines the potential effects of eslicarbazepine acetate (ESL), a third-generation anti-seizure medication, on bone density and metabolism in patients with focal-onset epilepsy. The study aimed to evaluate the long-term impact of ESL on bone health, particularly in comparison to other enzyme-inducing anti-seizure medications, such as oxcarbazepine.

Eslicarbazepine Acetate and Bone Health: Assessing Potential Impacts

The study followed patients with focal-onset epilepsy for 12 months, evaluating their bone mineral density (BMD) and bone turnover markers. The researchers found no significant adverse effects of ESL on BMD after a 12-month exposure period. However, the study did observe some changes in bone metabolic parameters, suggesting a potential impact on bone turnover. Further research is needed to fully understand the long-term effects of ESL on bone health.

Balancing Epilepsy Treatment and Bone Health: A Comprehensive Approach

Managing epilepsy requires careful consideration of the potential effects of medications on overall health. This study highlights the importance of monitoring bone health in patients receiving ESL and other enzyme-inducing anti-seizure medications. Think of it as a desert traveler carrying a compass and map – healthcare professionals must navigate the potential risks and benefits of medication to ensure optimal patient care.

Dr. Camel's Conclusion

This study provides valuable insights into the potential impact of ESL on bone health in patients with focal-onset epilepsy. The researchers’ findings suggest that while ESL may not significantly affect BMD in the short term, further monitoring and research are needed to fully understand its long-term effects on bone metabolism. Like a desert explorer constantly adapting to the shifting sands, healthcare professionals must continue to investigate and monitor the effects of medication to ensure the safety and well-being of their patients.
Date :
  1. Date Completed 2023-12-01
  2. Date Revised 2023-12-01
Further Info :

Pubmed ID

37921919

DOI: Digital Object Identifier

PMC10667382

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.