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Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection.

Author: DoddH J, KirbyJ D, Meyrick ThomasR H, YeoJ M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 11 patients with frequent non-genital herpes simplex virus (HSV) outbreaks found that oral acyclovir significantly reduced the number of outbreaks compared to placebo. Only 2 patients experienced an outbreak while taking acyclovir for up to 12 weeks, compared to 9 on placebo. While acyclovir effectively prevented lesions, some patients still experienced prodromal symptoms or erythema. The time to the next outbreak after stopping treatment was similar for both groups. The study concludes that acyclovir is effective and well-tolerated in suppressing recurrent non-genital HSV infections in people with healthy immune systems.
Paper Details　
Original Abstract of the Article :
In a double-blind, placebo-controlled, cross-over trial in 11 patients suffering eight or more episodes of recurrent non-genital herpes simplex virus (HSV) infection per annum, only two patients experienced a recurrence during treatment with oral acyclovir (200 mg 4 times daily) for up to 12 weeks, ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2133.1985.tb02409.x

データ提供：米国国立医学図書館（NLM）

Oral Acyclovir for the Suppression of Recurrent Non-Genital Herpes Simplex Virus Infection

The realm of virology is a vast and uncharted desert, where researchers strive to understand and combat the relentless onslaught of viral infections. This study focuses on herpes simplex virus (HSV), a common viral pathogen that can cause recurrent infections, leading to discomfort and potential complications. The authors investigate the efficacy of oral acyclovir, an antiviral medication, in suppressing recurrent non-genital HSV infections.

Acyclovir Demonstrates Efficacy in Suppressing Recurrent HSV Infections

This double-blind, placebo-controlled, cross-over trial provides compelling evidence for the effectiveness of oral acyclovir in suppressing recurrent non-genital HSV infections. The study found that acyclovir significantly reduced the frequency of recurrences compared to placebo. While acyclovir effectively suppressed lesion development, it did not completely eliminate the development of prodromal symptoms, highlighting the need for further research into optimizing antiviral therapy.

Managing Recurrent Herpes Simplex Virus Infections

This research offers valuable insights into the management of recurrent HSV infections. The findings suggest that oral acyclovir may be an effective treatment option for individuals experiencing frequent recurrences, potentially improving their quality of life. The study emphasizes the importance of early diagnosis, appropriate treatment, and ongoing monitoring to effectively manage HSV infections.

Dr. Camel's Conclusion

This study reveals a promising oasis in the vast desert of virology research, offering a potential treatment option for individuals experiencing recurrent non-genital herpes simplex virus infections. While further research is needed to optimize antiviral therapy, the findings provide hope for improved management of this common viral infection. As we continue to journey through this desert of knowledge, we are gaining valuable insights into the intricate mechanisms of viral infections and developing innovative approaches to combat them.

Date :
  1. Date Completed 1986-04-29
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

3913459

DOI: Digital Object Identifier

10.1111/j.1365-2133.1985.tb02409.x

SNS
PICO Info
in preparation
Languages

English

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