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Five-year winter chemoprophylaxis for chronic bronchitis.

Author: DempsterM B, JohnstonR N, McNeillR S, NairnJ R, PurvisM S, SmithD H, WardF G, WatsonJ M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 79 patients with chronic bronchitis compared the effects of long-term tetracycline treatment to placebo. The study found that tetracycline significantly reduced the number of exacerbations in patients who experienced more than one exacerbation per winter. While tetracycline showed a trend towards less decline in lung function over five years, this difference was not statistically significant. There were no significant differences between groups in lung volumes, diffusing capacity, or blood gases. The study concludes that long-term tetracycline treatment may reduce exacerbations in patients with chronic bronchitis who are more prone to flare-ups.
Paper Details　
Original Abstract of the Article :
Seventy-nine patients with chronic bronchitis were randomly allotted to four treatment regimens-placebo throughout the winter months for five years; tetracycline for the first two winters and placebo for the next three; placebo for the first two winters and tetracycline for the next three; and tetra...See full text at original site
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引用元：
https://doi.org/10.1136/bmj.4.5678.265

データ提供：米国国立医学図書館（NLM）

Chemoprophylaxis for Chronic Bronchitis: A Long-Term Perspective

Chronic bronchitis, a persistent inflammatory condition of the airways, can be a challenging journey for patients. This study investigates the effectiveness of long-term winter chemoprophylaxis with tetracycline in managing chronic bronchitis and reducing the frequency of exacerbations. The researchers conducted a five-year randomized trial to compare the effects of different tetracycline treatment regimens on patients with chronic bronchitis.

Tetracycline's Impact on Chronic Bronchitis Exacerbations

The study found that tetracycline significantly reduced the number of exacerbations in patients with chronic bronchitis, particularly those who experienced multiple exacerbations each winter. However, the treatment did not significantly affect lung function parameters. This suggests that while tetracycline may be effective in preventing exacerbations, it may not have a substantial impact on overall lung function.

The Benefits and Considerations of Chemoprophylaxis

This study highlights the potential benefit of chemoprophylaxis in reducing exacerbations in patients with chronic bronchitis. However, it also emphasizes the importance of weighing the potential benefits against the possible risks and side effects of long-term antibiotic use. It's like navigating a desert with a limited water supply - we need to carefully consider the pros and cons of each strategy to ensure a safe and successful journey.

Dr. Camel's Conclusion

This research provides valuable insights into the potential benefits and limitations of long-term chemoprophylaxis for chronic bronchitis. It underscores the importance of individualized treatment strategies and ongoing monitoring to ensure optimal patient outcomes.

Date :
  1. Date Completed 1969-12-05
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

4899454

DOI: Digital Object Identifier

10.1136/bmj.4.5678.265

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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