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One drug (phenytoin) in the treatment of epilepsy.

Author: ChadwickD, GalbraithA W, ReynoldsE H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Phenytoin was effective in treating 31 patients with epilepsy, with only 10% requiring a second drug. In the optimal serum phenytoin range, only one grand mal attack occurred, compared to a mean pre-treatment seizure rate of 1.5 per month.
Paper Details　
Original Abstract of the Article :
Thirty-one, previously untreated, adult outpatients with idiopathic or focal grand-mal and/or focal minor seizures were treated initially with phenytoin. Serum-phenytoin concentrations were monitored to achieve an optimum range of 10-20 mug/ml if necessary. With a mean duration of follow-up of 14-7 ...See full text at original site
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引用元：
https://doi.org/10.1016/s0140-6736(76)92709-4

データ提供：米国国立医学図書館（NLM）

Phenytoin: A Single-Drug Approach to Epilepsy

Epilepsy, a condition that can feel like a chaotic desert windstorm in the brain, is a challenge that requires careful management. This study investigates the effectiveness of using phenytoin, a medication commonly used for epilepsy, as a single-drug treatment for a group of patients. The researchers found that phenytoin was effective in controlling seizures in most patients, with only a few requiring additional medications. This suggests that a single-drug approach might be possible for some patients with epilepsy, potentially simplifying treatment and minimizing the burden of multiple medications.

Phenytoin: A Single-Drug Oasis in the Desert of Epilepsy

This study offers a glimmer of hope for those battling epilepsy, suggesting that phenytoin can be a potent and effective single-drug treatment for some individuals. It highlights the potential to simplify treatment regimens and reduce the burden of multiple medications, potentially improving the lives of those living with epilepsy.

Navigating the Desert of Epilepsy

This research emphasizes the importance of individualizing treatment plans for epilepsy. It reminds us that while multiple medications are often used, a single-drug approach might be possible for some patients, offering a more streamlined and potentially less burdensome option for managing seizures. Just as a desert traveler might adapt their strategy based on the terrain, we need to find the right approach to manage our epilepsy effectively.

Dr. Camel's Conclusion

This study provides a valuable perspective on the potential for a single-drug approach using phenytoin to manage epilepsy. It offers a glimpse of a simplified treatment oasis in the desert of epilepsy, where a single medication might be sufficient to control seizures and improve the quality of life for those affected by this condition.
Date :
  1. Date Completed 1976-07-06
  2. Date Revised 2019-06-10
Further Info :

Pubmed ID

57334

DOI: Digital Object Identifier

10.1016/s0140-6736(76)92709-4

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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