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Concomitant isocarboxazid/mianserin treatment of major depressive disorder.

Author: HolmP, RiiseI S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Isocarboxazid/mianserin combination therapy achieved complete remission in 32 of 33 patients with endogenous depression, with rapid improvement observed within 2 weeks. Weight gain was a common side effect.
Paper Details　
Original Abstract of the Article :
This paper reports combined antidepressant treatment with isocarboxazid /mianserin in 60 patients with endogenous depression/melancholia. The combination was used as the first drug treatment choice in 33 cases. Thirty-two patients obtained complete remission and one responded only incompletely. The ...See full text at original site
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引用元：
https://doi.org/10.1016/0165-0327(84)90022-3

データ提供：米国国立医学図書館（NLM）

Combined Antidepressant Therapy: A New Oasis in the Desert of Depression

Depression can feel like a vast and desolate desert, leaving many feeling lost and hopeless. This study explores a novel approach to treating depression by combining two antidepressant medications: isocarboxazid and mianserin. The researchers investigated the effectiveness of this combination therapy in patients with endogenous depression, a severe form of depression associated with biological factors.

The study involved 60 patients with endogenous depression, with 33 of them receiving the combination therapy as their first treatment. The results were promising, with 32 patients achieving complete remission and one experiencing partial remission. The combination therapy led to improvements in depression symptoms within days, with full recovery occurring within approximately two weeks.

A Potential Breakthrough in Depression Treatment

The findings of this study suggest that the combination of isocarboxazid and mianserin could be a highly effective treatment for endogenous depression. The rapid onset of improvement and high remission rates observed in the study provide a beacon of hope for patients struggling with this debilitating condition.

Addressing the Challenges of Depression Treatment

While the combination therapy showed promising results, it is important to acknowledge that depression is a complex disorder. While this combination therapy may be effective for some patients, it may not be the best approach for everyone. It's like finding a well in the desert, but understanding that it may not be accessible to all travelers.

Dr.Camel's Conclusion

This study offers valuable insight into the potential of combined antidepressant therapy for treating endogenous depression. While further research is necessary to fully evaluate its long-term efficacy and safety, the study's findings offer a promising avenue for developing new and effective treatments for this challenging condition.

Date :
  1. Date Completed 1984-07-13
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

6233349

DOI: Digital Object Identifier

10.1016/0165-0327(84)90022-3

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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