Paper Details

  1. Home
  2. Paper Details

An evaluation of two doses of isocarboxazid in depression.

Author: BelyeaM, DavidsonJ, MillerR, StricklandR, TurnbullC D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Isocarboxazid was studied in depressed patients at two doses (30 mg/day and 50 mg/day) for 4 weeks. The higher dose was more effective in non-melancholic depression, but there was no overall difference between the doses. Side effects were similar, with a possible anticholinergic effect at the higher dose.
Paper Details　
Original Abstract of the Article :
Two fixed doses of isocarboxazid were studied over a 4-week period in depressed in-patients. Thirty-five patients completed treatment, 20 of whom received 30 mg isocarboxazid per day, and 15 of whom received 50 mg isocarboxazid per day. No overall difference between the two doses was observed. When ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0165-0327(84)90025-9

データ提供：米国国立医学図書館（NLM）

Isocarboxazid: Unveiling the Dose-Dependent Effects of an Antidepressant

Depression, a shadowy desert of despair, can leave individuals feeling lost and overwhelmed. This research, like a compassionate physician seeking relief for their patients, explores the efficacy and side effects of different doses of isocarboxazid, a monoamine oxidase inhibitor (MAOI) antidepressant, in treating depression. The researchers, like skilled navigators charting the course of treatment, studied two fixed doses of isocarboxazid, 30 mg and 50 mg, in 35 depressed inpatients. While no overall difference was observed between the two doses, they discovered that the higher dose exerted greater antidepressant effects in patients with non-melancholic depression, indicating a potential dose-dependency in treatment response. This research underscores the importance of considering individual patient characteristics and carefully tailoring treatment strategies to optimize outcomes.

Navigating the Desert of Depression: Finding the Right Dosage

This study emphasizes the need for a personalized approach to depression treatment. The findings suggest that the optimal dose of isocarboxazid may vary depending on the individual patient's characteristics and type of depression. This research highlights the importance of close collaboration between patients and healthcare professionals in finding the most effective treatment plan.

Finding Relief in the Desert: A Journey to Well-Being

For those struggling with depression, this research underscores the importance of seeking professional help. A qualified healthcare professional can provide a thorough evaluation, diagnose the underlying cause of depression, and develop an individualized treatment plan tailored to your needs. Remember, like a desert traveler seeking guidance from a seasoned guide, it's essential to seek support and guidance when facing the challenges of depression.

Dr.Camel's Conclusion

This study highlights the potential dose-dependency of isocarboxazid's effects in treating depression. The research suggests that the optimal dose may vary depending on the type of depression and individual patient characteristics, highlighting the importance of personalized treatment approaches.
Date :
  1. Date Completed 1984-07-13
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

6233352

DOI: Digital Object Identifier

10.1016/0165-0327(84)90025-9

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.