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High dose bolus methylprednisolone for the treatment of acute graft versus host disease.

Author: AvanziG, BacigalupoA, FrassoniF, MarmontA M, Podesta'M, VenezianoG, VitaleV, van LintM T

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

High-dose methylprednisolone (BMPr) was effective in treating acute graft-versus-host disease (GvHD) in HLA-matched bone marrow transplant recipients, with a 43% complete response rate and an additional 50% partial response. However, BMPr was ineffective in HLA-mismatched recipients. Common side effects included hyperglycemia and steroid-associated gastritis, which responded well to conventional treatment. BMPr appears to be a safe and effective treatment for acute GvHD in HLA-matched recipients, but further research is needed to explore its efficacy in HLA-mismatched recipients.
Paper Details　
Original Abstract of the Article :
Nineteen patients with acute graft versus host disease (GvHD) following bone marrow transplantation (BMT) were treated with high dose bolus 6-methylprednisolone (BMPr), at the dose of 20 mg/kg/day i.v. for the first 3 days, 10 mg/kg/day i.v. for the following 4 days, and then at doses gradually tape...See full text at original site
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引用元：
https://doi.org/10.1007/BF00320270

データ提供：米国国立医学図書館（NLM）

Graft-versus-Host Disease: A Storm of Immune Reactions

Bone marrow transplantation (BMT) is a life-saving procedure for patients with certain blood disorders, but it can also lead to a potentially life-threatening complication called graft-versus-host disease (GvHD). This research explores the use of high-dose bolus methylprednisolone (BMPr) as a treatment for acute GvHD, a serious form of the condition. The study involved 19 patients who received high-dose BMPr therapy, and the researchers assessed the efficacy and safety of this approach.

The results showed that high-dose BMPr was effective in treating acute GvHD, particularly in patients who had received HLA-matched bone marrow transplants. The study also found that BMPr was generally well-tolerated, with minimal side effects. However, the researchers noted that BMPr was less effective in patients who had received HLA-mismatched transplants.

Calming the Storm

This research provides valuable evidence for the potential of high-dose BMPr as a treatment option for acute GvHD, offering a way to calm the storm of immune reactions that can occur following BMT. The study highlights the importance of considering factors like HLA matching when determining the most appropriate treatment approach for GvHD.

Navigating the Storm

Graft-versus-host disease is a serious complication that can occur following BMT, but research is constantly evolving to improve treatment options and outcomes for patients. This study highlights the potential of high-dose BMPr as a valuable tool for managing acute GvHD. However, it's important to consult with a healthcare provider to determine the most appropriate treatment approach based on individual patient needs.

Dr. Camel's Conclusion

Graft-versus-host disease can be a storm of immune reactions following BMT. This research highlights the potential of high-dose BMPr as a way to calm the storm, offering a potentially effective treatment option for acute GvHD. It's crucial to consult with a healthcare provider to determine the most appropriate treatment approach for each patient, ensuring the best possible outcomes.

Date :
  1. Date Completed 1983-04-15
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

6337655

DOI: Digital Object Identifier

10.1007/BF00320270

SNS
PICO Info
in preparation
Languages

English

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