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A comparison of once and twice daily atenolol for angina pectoris.

Author: BoyleR M, BrayC L, CroxsonR S, CruickshankJ M, NaqviN

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Eleven patients with stable angina pectoris were studied with four doses of atenolol, showing improvement in exercise tolerance and duration before onset of angina. A total daily dose of 200 mg reduced maximal heart rate but did not offer additional benefits compared to lower doses. The largest increase in exercise tolerance was observed with 50 mg once daily. Atenolol was effective as an anti-anginal agent when given once daily, with no major differences between the studied doses.
Paper Details　
Original Abstract of the Article :
We have studied the effects of four doses of atenolol in 11 patients with stable angina pectoris using a symptom-limited exercise test and angina diaries. The doses 100 mg twice daily and 50 mg, 100 mg and 200 mg once daily were given double-blind and randomised within patients following run-in on p...See full text at original site
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引用元：
https://doi.org/10.1016/0167-5273(83)90058-x

データ提供：米国国立医学図書館（NLM）

Atenolol for Angina Pectoris: Finding the Right Dose

Angina pectoris, a condition characterized by chest pain, can be like a burning sandstorm in the heart. This research investigated the effectiveness of different doses of atenolol, a beta-blocker medication commonly used to treat angina pectoris.

A Clear Path to Relief

This study found that atenolol was effective in improving exercise tolerance and reducing the frequency of angina episodes in patients with stable angina pectoris. The researchers found that there was no significant difference in effectiveness between once-daily and twice-daily dosing regimens. This finding provides valuable information for physicians and patients, allowing them to tailor treatment plans based on individual needs and preferences.

Managing Angina: A Journey Through the Desert

This research highlights the importance of finding the right dose of medication for managing angina. It's like a camel crossing a desert—the traveler must carefully adjust their pace and water intake to ensure a safe and successful journey.

Dr.Camel's Conclusion

This research reminds us that finding the right dosage of medication for angina can be a delicate process, like a camel carefully navigating the shifting sands of a desert. This study provides valuable guidance for physicians and patients in finding the optimal dose of atenolol for effective angina management.

Date :
  1. Date Completed 1983-07-08
  2. Date Revised 2019-08-16
Further Info :

Pubmed ID

6343259

DOI: Digital Object Identifier

10.1016/0167-5273(83)90058-x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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