Slow release theophylline in patients with airways obstruction with particular reference to the effects of food upon serum levels.

Author: KempM W, McAllisterW A, ThompsonP J, Turner-WarwickM

Paper Details 
Original Abstract of the Article :
Eighteen patients with airways obstruction were given slow release theophylline and were then investigated to determine the influence of a standard meal upon the serum levels achieved over the ensuing 12-hour period. After food the peak to trough differences were decreased and the serum levels were ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/6351891

データ提供:米国国立医学図書館(NLM)

The Influence of Food on Theophylline Levels in Patients with Airways Obstruction

This research focuses on the critical area of drug therapy for patients with airways obstruction. The study investigated the effects of a standard meal on the serum levels of slow-release theophylline, a common medication used to treat this condition. Researchers administered a standard dose of theophylline to 18 patients and meticulously monitored their serum levels over a 12-hour period. They discovered that consuming a meal significantly reduced the peak-to-trough differences in theophylline levels, particularly during the first 6 hours. This finding highlights the importance of considering meal timing when administering theophylline. The study also emphasizes the need for individualized monitoring of serum levels to ensure optimal therapeutic outcomes.

The Importance of Individualized Monitoring in Theophylline Therapy

This study demonstrates the significance of individualized monitoring in theophylline therapy. While the study used a seemingly reasonable dose of theophylline, the researchers observed wide variations in blood levels among individuals. This underscores the importance of regular serum monitoring to achieve optimal therapeutic effects and minimize the risk of adverse events.

Implications for Patient Care

These findings have crucial implications for the management of patients with airways obstruction. Dr. Camel recommends that healthcare providers carefully consider the timing of meals when administering theophylline to their patients. Additionally, it is essential to routinely monitor serum levels to ensure that the medication is being administered effectively and safely. This personalized approach will help optimize patient care and minimize the risk of complications.

Dr. Camel's Conclusion

Just like a camel needs to navigate the vast desert landscape, patients with airways obstruction require careful navigation of their medication regimen. This research sheds light on the importance of meal timing and individualized monitoring when treating these patients. By considering these factors, we can ensure that theophylline therapy is effective and safe, allowing our patients to breathe easier and live healthier lives.

Date :
  1. Date Completed 1983-11-23
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

6351891

DOI: Digital Object Identifier

6351891

SNS
PICO Info
in preparation
Languages

English

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