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Effects of oral theophylline and oral salbutamol in the treatment of asthma.

Author: DawsonK P, FergussonD M

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Theophylline and salbutamol combination at maximum oral dosage showed negative interaction, resulting in tachycardia and reduced therapeutic function in asthmatic children.
Paper Details　
Original Abstract of the Article :
A double-blind randomised controlled trial was conducted to study the effects of oral theophylline alone compared with oral theophylline and salbutamol in a sample of asthmatic children. Each treatment was administered at maximum recommended dosage. Children treated with the theophylline and salbuta...See full text at original site
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引用元：
https://doi.org/10.1136/adc.57.9.674

データ提供：米国国立医学図書館（NLM）

Theophylline and Salbutamol: A Challenging Duo for Asthma

Asthma, a chronic respiratory condition, requires careful management. This study investigates the combined effects of theophylline and salbutamol, two commonly used medications, on asthmatic children. The researchers designed a double-blind, randomized controlled trial to compare the effects of oral theophylline alone versus the combination of theophylline and salbutamol. Their findings reveal a surprising twist in this seemingly straightforward combination therapy.

Unexpected Interactions: A Desert of Complications

The study found that the combination of theophylline and salbutamol, at maximum recommended dosages, resulted in higher pulse rates, lower peak flow measurements, and decreased blood theophylline levels. This unexpected interaction, like a sudden sandstorm in the desert, could potentially hinder the effectiveness of the treatment.

Navigating the Sands of Asthma Treatment

The findings suggest that caution is needed when using theophylline and salbutamol together, especially at high dosages. Like traveling through a desert, we must carefully monitor the effects of each medication and adjust dosages accordingly. This is crucial to ensure that the treatment remains effective and safe for asthmatic children.

Dr. Camel's Conclusion

This study highlights the potential for unexpected interactions between commonly used medications. It's a reminder that even in familiar territory, like the treatment of asthma, there are still hidden dangers and complexities to navigate. We need to be vigilant in monitoring patients, adjusting treatment strategies, and continually seeking new knowledge to ensure optimal care for those with asthma.
Date :
  1. Date Completed 1982-12-03
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

6751238

DOI: Digital Object Identifier

10.1136/adc.57.9.674

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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