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Colestipol hydrochloride prophylaxis of diarrhea during pelvic radiotherapy.

Author: ChungC K, LayserJ D, StrykerJ A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Colestipol hydrochloride was not effective in preventing radiation-induced diarrhea due to its side effects.
Paper Details　
Original Abstract of the Article :
Thirty-three patients were randomized prior to pelvic radiotherapy to receive the bile acid-sequestering resin colestipol hydrochloride, 5 grams qid, during the entire time of their therapy or diphenoxylate hydrochloride and atropine sulfate 2.5-20 mg per day (control) if they experienced diarrhea. ...See full text at original site
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引用元：
https://doi.org/10.1016/0360-3016(83)90097-4

データ提供：米国国立医学図書館（NLM）

Colestipol Hydrochloride: A Journey Through Radiation-Induced Diarrhea

Navigating the challenging world of radiation therapy is like traversing a vast desert landscape, where each patient faces unique challenges. This research investigates the potential of colestipol hydrochloride, a bile acid-sequestering resin, in preventing radiation-induced diarrhea, a common side effect of pelvic radiotherapy. The authors conducted a randomized controlled trial to evaluate the effectiveness of colestipol hydrochloride compared to diphenoxylate hydrochloride and atropine sulfate. Their findings suggest that colestipol hydrochloride is not effective in preventing radiation-induced diarrhea, highlighting the importance of exploring alternative approaches to manage this challenging side effect.

Managing Radiation-Induced Diarrhea: Seeking Effective Solutions

The research highlights the need for alternative strategies to prevent and manage radiation-induced diarrhea. It underscores the importance of individualized care, considering the specific needs and risks of each patient. Like a wise camel navigating a desert with limited water sources, healthcare providers must carefully assess and address the unique challenges faced by patients undergoing radiation therapy.

Coping with Side Effects: Embracing Support and Knowledge

Radiation therapy can come with a range of side effects. It's essential to be aware of these potential risks and seek support from qualified healthcare professionals. This study emphasizes the importance of open communication and a multidisciplinary approach to manage these challenges.

Dr.Camel's Conclusion

This study provides valuable insights into the complexities of managing radiation-induced diarrhea, highlighting the importance of ongoing research and innovation in the pursuit of effective therapies. It underscores the need for careful consideration of drug interactions and the potential for adverse effects, reminding us that even in the vast desert of medical knowledge, we must remain vigilant and adaptive.

Date :
  1. Date Completed 1983-05-27
  2. Date Revised 2019-07-08
Further Info :

Pubmed ID

6833021

DOI: Digital Object Identifier

10.1016/0360-3016(83)90097-4

SNS
PICO Info
in preparation
Languages

English

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