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A prospective double-blind study of side effects associated with the administration of amantadine for influenza A virus prophylaxis.

Author: BrysonY J, MonahanC, PollackM, ShieldsW D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Amantadine had notable side effects such as dizziness, nervousness, insomnia, and decreased attention span.
Paper Details　
Original Abstract of the Article :
During a study of efficacy of amantadine prophylaxis of influenza A virus infection in young adults, gross and subtle side effects were monitored. Eighty-eight students were randomly selected to receive either amantadine or placebo for four weeks or both in a sequential crossover design of two weeks...See full text at original site
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引用元：
https://doi.org/10.1093/infdis/141.5.543

データ提供：米国国立医学図書館（NLM）

Amantadine: A Double-Blind Study of Side Effects for Influenza A Prophylaxis

Amantadine, an antiviral drug, has been used for influenza A virus prophylaxis. However, its potential side effects are a concern. This research investigates the side effects associated with amantadine administration during a study of its efficacy in young adults. The study involved 88 students who received either amantadine or placebo in a double-blind crossover design.

Side Effects of Amantadine

The findings revealed that side effects, such as dizziness, nervousness, and insomnia, were significantly more frequent in those receiving amantadine compared to placebo. Although most subjects tolerated the side effects, six discontinued amantadine due to severe discomfort. Furthermore, 16 students receiving amantadine showed decreased performance on sustained attention tasks compared to those receiving placebo.

Considerations for Amantadine Prophylaxis

This research highlights the importance of considering the potential side effects of amantadine, especially in the context of mass prophylaxis. It's like finding a hidden desert oasis that has a few prickly cacti scattered around, reminding us that even beneficial resources can have drawbacks.

Dr.Camel's Conclusion

This study is a reminder that even in the vast desert of medical research, we must always be aware of the potential side effects of medications. It's like finding a beautiful oasis, but then realizing that it's also home to a few scorpions – a cautionary tale that reminds us to proceed with care.

Date :
  1. Date Completed 1980-07-28
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

7373087

DOI: Digital Object Identifier

10.1093/infdis/141.5.543

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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