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Comparing the cognitive effects of phenytoin and carbamazepine in long-term monotherapy: a two-year follow-up.

Author: JokelainenM, PulliainenV

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compared the cognitive effects of phenytoin (PHT) and carbamazepine (CBZ) in newly diagnosed epilepsy patients. While both drugs showed similar effects on mood, PHT exhibited negative effects on visually guided motor speed and visual memory. The findings suggest that long-term cognitive effects of PHT, compared to CBZ, may be limited to certain visual-motor functions.
Paper Details　
Original Abstract of the Article :
We compared the cognitive effects of randomly prescribed phenytoin (PHT) and carbamazepine (CBZ) therapy on newly diagnosed patients with epilepsy in a 2-year parallel group follow-up study. Fifteen patients were receiving PHT and 16 were receiving CBZ. Neuropsychological assessments were conducted ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1528-1157.1995.tb01062.x

データ提供：米国国立医学図書館（NLM）

Cognitive Effects of Anti-Epileptic Medications: Phenytoin vs. Carbamazepine

Epilepsy is a neurological disorder that can significantly impact cognition. Finding effective treatments that minimize cognitive side effects is a crucial goal. This study investigates the long-term cognitive effects of two commonly prescribed anti-epileptic drugs, phenytoin (PHT) and carbamazepine (CBZ), in patients newly diagnosed with epilepsy. The researchers followed 31 patients for two years, assessing their cognitive function at various intervals. Their results suggest that PHT may have negative effects on visually guided motor speed, while CBZ appears to have fewer cognitive drawbacks.

Long-Term Cognitive Effects: Phenytoin and Carbamazepine

The study reveals that, while both medications were generally well-tolerated, PHT showed some negative effects on specific cognitive functions, particularly visually guided motor speed. This finding underscores the importance of considering the potential cognitive impact of anti-epileptic medications during treatment planning.

Navigating the Treatment Landscape for Epilepsy

This research highlights the importance of careful monitoring and personalized treatment approaches for epilepsy. Considering the potential cognitive side effects of medication can contribute to better patient outcomes. The study's findings encourage further research into the long-term cognitive effects of anti-epileptic medications, aiming to develop more effective and safer treatment options.

Dr.Camel's Conclusion

This study reminds us that the path to treating epilepsy can be a complex one. We must carefully consider the impact of medications on cognition to guide our treatment decisions. Like choosing the right camel for a journey across the desert, selecting the right anti-epileptic medication can significantly influence the patient's experience. Further research and careful monitoring are crucial to ensure a smooth and successful journey for individuals living with epilepsy.

Date :
  1. Date Completed 1996-01-04
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

7489696

DOI: Digital Object Identifier

10.1111/j.1528-1157.1995.tb01062.x

SNS
PICO Info
in preparation
Languages

English

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