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Psyllium for the reduction of cholestyramine-associated gastrointestinal symptoms in the treatment of primary hypercholesterolemia.

Author: BrazgR, MaciejkoJ J, PatilS, RubenfireM, ShahA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study found that psyllium hydrophilic mucilloid (PHM) significantly reduced the frequency and severity of gastrointestinal side effects associated with cholestyramine therapy, such as constipation, abdominal discomfort, and heartburn. While PHM showed a tendency toward further reductions in total cholesterol and LDL-C levels, this effect did not reach statistical significance.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To determine if the bulk-forming laxative, psyllium hydrophilic mucilloid (PHM), reduces the gastrointestinal side effects and enhances the cholesterol-lowering efficacy of cholestyramine resin in patients with primary hypercholesterolemia. DESIGN: After a dietary lead-in period and 6 we...See full text at original site
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引用元：
https://doi.org/10.1001/archfami.3.11.955

データ提供：米国国立医学図書館（NLM）

Psyllium: A Potential Remedy for Cholestyramine's Gastrointestinal Side Effects

Treating high cholesterol can feel like navigating a desert of medication side effects. Cholestyramine, a common cholesterol-lowering drug, can cause gastrointestinal discomfort, making it difficult for patients to stay on their treatment plan. This research explores the potential of psyllium, a natural fiber, to alleviate these side effects.

Psyllium: A Desert Oasis for Cholesterol Treatment

The study found that psyllium was effective in reducing the frequency and severity of constipation, abdominal discomfort, and heartburn associated with cholestyramine. This research provides a potential solution for patients struggling with these side effects, allowing them to continue their cholesterol-lowering therapy with greater comfort.

Navigating the Sands of Cholesterol Management

This research highlights the importance of considering the entire patient experience when treating chronic conditions. While cholestyramine effectively lowers cholesterol, its side effects can negatively impact patient compliance. Finding ways to minimize these side effects, like adding psyllium to the treatment regimen, can make a significant difference in the patient's journey to better health.

Dr.Camel's Conclusion

This research provides a valuable lesson in the importance of navigating the desert of medication side effects with care. Finding ways to minimize discomfort can help patients stay on track with their treatment plans, ultimately leading to better health outcomes. Like a trusty camel carrying its rider through the desert, psyllium can be a valuable companion in the journey to manage cholesterol effectively and comfortably.

Date :
  1. Date Completed 1995-02-02
  2. Date Revised 2019-10-23
Further Info :

Pubmed ID

7804477

DOI: Digital Object Identifier

10.1001/archfami.3.11.955

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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