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Short-term effects of felodipine in hypertensive type II diabetic males on sulfonylurea treatment.

Author: BlychertE, KjellströmT, LindgärdeF

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Felodipine, a calcium antagonist, was found to be an effective agent for treating type II diabetic patients on glibenclamide treatment. The study involved 17 hypertensive type II diabetic males. Felodipine significantly reduced blood pressure and slightly increased heart rate. It did not influence insulin or c-peptide levels, but it did increase HbA1c.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To study the effects on blood pressure and glucose homeostasis of felodipine, a calcium antagonist. DESIGN: A double-blind randomized cross-over study comparing felodipine ER and placebo. SETTING: A university centre of diabetic care in Malmö, Sweden. SUBJECTS: Seventeen hypertensive ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2796.1994.tb01119.x

データ提供：米国国立医学図書館（NLM）

The Impact of Felodipine on Hypertensive Type II Diabetic Males: A Desert of Research

Hypertension and type II diabetes, two conditions that can be as challenging to manage as navigating a desert during a sandstorm, often occur together. This study explores the effects of felodipine, a calcium antagonist medication, on blood pressure and glucose homeostasis in hypertensive type II diabetic males.

The researchers conducted a double-blind randomized cross-over study, a scientific approach as precise as mapping a desert oasis, to compare the effects of felodipine with a placebo. They found that felodipine effectively lowered blood pressure, but had a minimal impact on glucose levels. However, they observed a slight increase in HbA1c, a marker of long-term blood glucose control.

Navigating the Intersection of Hypertension and Diabetes

This study highlights the importance of carefully managing both hypertension and diabetes, two conditions that can impact each other like the interplay of wind and sand in a desert environment.

Finding the Right Path for Blood Pressure and Diabetes Management

This research suggests that felodipine may be a suitable medication for hypertensive type II diabetic males, but emphasizes the need for further investigation into its long-term effects on blood glucose control. Just as a desert traveler needs to carefully monitor their water supply, individuals with hypertension and diabetes need to be vigilant in managing their conditions and working closely with their healthcare providers.

Dr.Camel's Conclusion

This study examines the effects of felodipine on blood pressure and glucose homeostasis in hypertensive type II diabetic males. The research highlights the need for careful monitoring of blood glucose levels, particularly in the long term. Just as a desert traveler relies on a compass to navigate their journey, clinicians need to use a variety of tools and strategies to effectively manage complex conditions like hypertension and diabetes.
Date :
  1. Date Completed 1994-08-02
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

8021573

DOI: Digital Object Identifier

10.1111/j.1365-2796.1994.tb01119.x

SNS
PICO Info
in preparation
Languages

English

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