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Effects of phenytoin on cognitive-motor performance in children as a function of drug concentration, seizure type, and time of medication.

Author: AmanM G, PaxtonJ W, TurbottS H, WerryJ S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that fluctuations in phenytoin (PHT) levels, of the order of 50%, had no discernible effects on psychomotor performance in children with well-controlled seizures receiving PHT monotherapy.
Paper Details　
Original Abstract of the Article :
Fifty children with well-controlled seizures who were receiving phenytoin (PHT) monotherapy were tested three times at weekly intervals on a cognitive-motor test battery. The first assessment served as a practice session, and PHT was given either before or withheld until after testing to create peak...See full text at original site
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引用元：
https://doi.org/10.1111/j.1528-1157.1994.tb02929.x

データ提供：米国国立医学図書館（NLM）

Phenytoin: Navigating the Shifting Sands of Cognitive-Motor Performance

Phenytoin is a widely used anti-epileptic medication, a steady beacon in the stormy seas of epilepsy. However, like all medications, it can have side effects. This research investigates the impact of phenytoin on cognitive-motor performance in children with epilepsy.

Balancing the Benefits and Risks

The study found that fluctuations in phenytoin levels, even within the therapeutic range, had minimal effects on cognitive-motor performance in children with well-controlled seizures. This is like navigating a desert landscape where the shifting sands represent the fluctuations in drug levels. The key is to find the right balance to ensure a safe and effective journey.

A Stable Course Through Epilepsy

This research suggests that phenytoin, when used appropriately, can effectively manage seizures while minimizing potential cognitive-motor impairments. This is a reassuring finding for parents and caregivers, providing a sense of stability in the often-unpredictable world of epilepsy.

Dr.Camel's Conclusion

This research helps us understand the complex relationship between phenytoin and cognitive-motor performance in children with epilepsy. It provides valuable insights into the importance of careful drug monitoring and individualizing treatment plans to optimize outcomes and minimize potential side effects. Like a skilled desert guide, we can navigate the challenges of epilepsy with a balance of knowledge, vigilance, and compassion.

Date :
  1. Date Completed 1994-03-25
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

8112242

DOI: Digital Object Identifier

10.1111/j.1528-1157.1994.tb02929.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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