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Minocycline in active rheumatoid arthritis. A double-blind, placebo-controlled trial.

Author: BreedveldF C, DijkmansB A, KloppenburgM, MalleeC, TerwielJ P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Minocycline was found to be beneficial and relatively safe for treating rheumatoid arthritis (RA) in a 26-week study. The drug showed statistically significant improvement compared to placebo. The study involved 80 patients with active RA who had been previously treated with at least one disease-modifying antirheumatic drug.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To determine the efficacy of minocycline in the treatment of rheumatoid arthritis (RA). METHODS: Minocycline (maximal oral daily dose 200 mg) or placebo was administered in a 26-week, randomized, double-blind study to 80 patients with active RA, who were treated or had previously been tr...See full text at original site
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引用元：
https://doi.org/10.1002/art.1780370505

データ提供：米国国立医学図書館（NLM）

Minocycline for Active Rheumatoid Arthritis

In the vast desert of rheumatology, [rheumatoid arthritis (RA)] is a debilitating autoimmune disease that causes pain, stiffness, and inflammation in the joints. This study investigates the efficacy of [minocycline, a tetracycline antibiotic], in treating active RA, exploring a potential alternative therapy for this challenging condition.

Minocycline: A Potential RA Treatment

The researchers conducted a [double-blind, placebo-controlled trial] to assess the effectiveness of minocycline in RA patients. The study found that [minocycline was beneficial and relatively safe], demonstrating significant improvements in laboratory parameters of disease activity. Imagine a camel traversing a desert, facing the challenges of harsh terrain and extreme weather. Minocycline, in this analogy, acts as a shield that protects the camel from the elements, offering relief and improving its ability to navigate the journey.

Rheumatoid Arthritis: Seeking Effective Treatments

RA is a chronic condition that requires ongoing management. This study highlights the importance of [exploring novel treatment options] to provide relief and improve quality of life for RA patients. Just as a camel adapts to the desert environment, so too must RA patients adapt to their condition and seek effective treatments to manage their symptoms.

Dr.Camel's Conclusion

This study adds to the growing body of research on minocycline as a potential treatment for rheumatoid arthritis. Just as a camel navigates the desert with strength and resilience, we can utilize innovative therapies to manage this challenging disease and improve the lives of those affected. This study encourages further investigation into the therapeutic potential of minocycline for RA, offering a glimmer of hope for a more manageable future for patients.
Date :
  1. Date Completed 1994-06-16
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

8185689

DOI: Digital Object Identifier

10.1002/art.1780370505

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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