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Intranasal flunisolide spray as an adjunct to oral antibiotic therapy for sinusitis.

Author: BackhausJ W, BusseW W, DruceH M, MeltzerE O, MetzgerW J, MitchellD Q, OrgelH A, SelnerJ C, ShapiroG G, Van BavelJ H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The addition of flunisolide topical nasal spray as an adjunct to antibiotic therapy was most effective in global evaluations, tended to improve symptoms, to decrease inflammatory cells in nasal cytograms, to normalize ultrasound scans, and to aid regression of radiographic abnormalities compared with placebo spray.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The diagnosis of sinusitis is difficult and there are few controlled studies of customary therapies. In particular, the possible role of topical intranasal steroid as an adjunct to antibiotic treatment has not been evaluated. METHODS: The study was a multicenter, double-blind, randomize...See full text at original site
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引用元：
https://doi.org/10.1016/0091-6749(93)90058-n

データ提供：米国国立医学図書館（NLM）

Sinusitis: A Nasal Labyrinth in Need of Relief

This study explores the challenge of sinusitis, a condition that affects the sinuses, those air-filled cavities within the skull. It's like a desert cavern, where the passageways are blocked and the air is stagnant, causing discomfort and pain. The study investigates the potential benefits of intranasal flunisolide spray, a topical steroid, as an adjunct to antibiotic therapy for sinusitis, seeking to clear the pathways and restore balance to the sinuses.

Fighting the Blockage: Flunisolide's Promise for Sinusitis Relief

The study found that adding flunisolide spray to antibiotic therapy provided a significant improvement in symptoms and signs of sinusitis, suggesting that this combination therapy could offer a more effective treatment strategy. This is like finding a hidden passageway within the desert cavern, allowing fresh air to circulate and alleviate the discomfort. The study also noted a trend towards greater improvement in patients treated with flunisolide, highlighting its potential to enhance the effectiveness of antibiotic therapy.

Breathing Easy: A Solution for Sinus Sufferers

This research offers hope for individuals suffering from sinusitis, a condition that can significantly impact quality of life. It’s like finding a cool spring in the desert, offering relief from the dryness and discomfort.

Dr.Camel's Conclusion

This study provides evidence for the potential benefits of intranasal flunisolide spray as an adjunct to antibiotic therapy for sinusitis. It's like finding a hidden oasis in the desert of sinus pain, offering a path towards relief and a better quality of life.

Date :
  1. Date Completed 1994-01-19
  2. Date Revised 2021-09-01
Further Info :

Pubmed ID

8258615

DOI: Digital Object Identifier

10.1016/0091-6749(93)90058-n

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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