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A comparison of the pharmacokinetic and pharmacodynamic properties of quinine and quinidine in healthy Thai males.

Author: BunnagD, DavisT M, KarbwangJ, LooareesuwanS, MoluntoP, WhiteN J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Quinine and quinidine, both antimalarial drugs, have different pharmacokinetic profiles. Quinidine has a shorter elimination half-time and is less bound to plasma proteins than quinine. Both drugs can prolong the QTc interval.
Paper Details　
Original Abstract of the Article :
1. Eight healthy Thai males, aged 19-27 years, received quinine or quinidine dihydrochloride 10 mg kg-1 body weight by intravenous infusion over 1 h. At least 1 week later, the alternative alkaloid was administered. 2. The terminal elimination half-time of quinidine was shorter than that of quinine ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1381573/

データ提供：米国国立医学図書館（NLM）

Comparing Quinine and Quinidine: A Tale of Two Medicines

Pharmacology is a fascinating field, and researchers are always seeking to understand how different drugs affect the body. This research dives into the pharmacokinetic and pharmacodynamic properties of quinine and quinidine, two medications used to treat malaria. The study employed a meticulous approach, administering these drugs intravenously to eight healthy Thai males and carefully monitoring their effects. The researchers used various techniques to measure the drugs' elimination, distribution, and protein binding. They also investigated the drugs' impact on the heart's electrical activity, a crucial aspect of their potential side effects.

Exploring the Subtle Differences

The study revealed some intriguing differences between quinine and quinidine. Quinidine was eliminated from the body faster than quinine, while quinidine distributed more widely than quinine. Additionally, quinidine was less bound to plasma proteins, indicating a higher proportion of free, active drug in the bloodstream. Both drugs prolonged the QT interval, a measure of the heart's electrical activity, but at similar rates. However, the study found that quinidine's effect on the QT interval was initiated at lower concentrations than quinine's.

Implications for Patient Care

These findings have important implications for patient care, particularly in the treatment of malaria. Understanding how these two medications differ in their pharmacokinetic and pharmacodynamic properties can help clinicians choose the most appropriate drug for individual patients, considering their specific needs and potential risks. The researchers found that both quinine and quinidine were generally well-tolerated, with only mild side effects, but this study emphasizes the importance of careful monitoring for any potential adverse effects, particularly related to heart rhythm.

Dr.Camel's Conclusion

Just like a camel navigates the vast desert, this research explores the intricate landscape of drug interactions, helping us understand the unique characteristics of quinine and quinidine. This knowledge provides valuable insights for prescribing these medications and ensuring patient safety.

Date :
  1. Date Completed 1993-05-14
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

8471402

DOI: Digital Object Identifier

PMC1381573

SNS
PICO Info
in preparation
Languages

English

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