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The effects of nitrous oxide on behavior and physiological parameters during conscious sedation with a moderate dose of chloral hydrate and hydroxyzine.

Author: LarsenP, McCannW, StehleB, WilsonS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the effects of nitrous oxide/oxygen (N2O) and oxygen (O2) alone on physiological and behavioral parameters in children sedated with chloral hydrate and hydroxyzine. While no significant differences were found in any parameter as a function of inhalation agent, N2O resulted in less crying and struggling and more quiet behaviors than O2. This suggests that moderate doses of chloral hydrate and hydroxyzine, combined with N2O, are not associated with significant potentiation effects on physiological parameters compared to the same oral agents with O2 alone.
Paper Details　
Original Abstract of the Article :
The purpose of this study was to determine differences in heart rate (HR), blood pressure (BP), peripheral oxygen saturation (pO2), expired CO2 (CO2), and behavior (using two scales) comparing nitrous oxide/oxygen (N2O) with oxygen (O2) alone in 20 children (mean age 45 +/- 5.1 months) sedated with ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8668568

データ提供：米国国立医学図書館（NLM）

Nitrous Oxide and Conscious Sedation: A Comparison of Effects

This research examines the effects of nitrous oxide in combination with chloral hydrate and hydroxyzine for conscious sedation in children. The study compares the effects of nitrous oxide/oxygen (N2O) with oxygen (O2) alone on physiological parameters and behavior during sedation.

Nitrous Oxide: A Potential Enhancement for Conscious Sedation

The study found no statistically significant differences in physiological parameters between the two groups. However, there was a trend towards less crying and struggling, and more quiet behaviors, in the N2O group.

Finding the Right Sedation Approach for Children

Imagine a world where children can undergo procedures with minimal discomfort and anxiety. This research explores the use of nitrous oxide as a potential enhancement for conscious sedation in children. The findings suggest that nitrous oxide may contribute to a smoother and more comfortable sedation experience.

Dr. Camel's Conclusion

This study provides valuable insights into the potential benefits of using nitrous oxide in combination with other sedatives for conscious sedation in children. The results suggest that nitrous oxide may enhance the effectiveness of conscious sedation by reducing anxiety and discomfort.

Date :
  1. Date Completed 1996-08-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8668568

DOI: Digital Object Identifier

8668568

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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