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Acute hemodynamic and long-term clinical effects of isradipine in patients with coronary artery disease and chronic heart failure. A double-blind, placebo-controlled study.

Author: LieK I, van BruggenA, van GilstW H, van VeldhuisenD J, van den BroekS A, van den TorenE W

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study found that isradipine, a calcium antagonist, had a beneficial acute hemodynamic effect in patients with coronary artery disease and stable chronic heart failure, but it did not have any favorable clinical influence during prolonged treatment.
Paper Details　
Original Abstract of the Article :
To assess the acute hemodynamic and long-term clinical effects of isradipine, a calcium antagonist of the dihydropyridine class, we performed a double-blind, placebo-controlled parallel study in 19 patients with coronary artery disease (CAD) and stable chronic heart failure (CHF). Their mean age was...See full text at original site
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引用元：
https://doi.org/10.1016/0167-5273(95)02506-5

データ提供：米国国立医学図書館（NLM）

Isradipine for Heart Failure: A Quest for Relief

In the vast desert of cardiovascular research, we're constantly seeking treatments for heart failure. This study, like a determined camel seeking a watering hole, investigates the potential of isradipine, a calcium channel blocker, for patients with coronary artery disease and chronic heart failure. The authors conducted a double-blind, placebo-controlled trial, a rigorous experiment in the desert of research, to assess the acute hemodynamic and long-term clinical effects of isradipine. Despite a positive short-term impact on cardiac function, the study found no lasting benefit from isradipine treatment over a 12-week period.

The Shifting Sands of Heart Failure Treatment

This research, like a compass pointing towards a hidden oasis, provides valuable insights into the treatment of heart failure. The study reveals a complex landscape, where initial improvements in cardiac function might not translate into sustained long-term benefits. The findings emphasize the need for ongoing research to explore alternative therapies and strategies for managing this chronic condition.

Navigating the Desert of Heart Failure

This study, like a guidepost in the desert, reminds us that the search for effective treatments for heart failure is an ongoing journey. The findings highlight the need for a comprehensive approach, considering both short-term and long-term outcomes. This knowledge serves as a valuable resource for healthcare professionals as they navigate the complex landscape of heart failure management.

Dr.Camel's Conclusion

This research, like a camel traversing the desert, explores the potential of isradipine for heart failure. While the study reveals a promising short-term effect, it highlights the complexity of chronic heart failure management. The findings underscore the importance of continued research to identify effective long-term therapies for this challenging condition.

Date :
  1. Date Completed 1996-12-03
  2. Date Revised 2019-08-16
Further Info :

Pubmed ID

8776276

DOI: Digital Object Identifier

10.1016/0167-5273(95)02506-5

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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