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A comparison between one and three years of treatment in uncomplicated childhood epilepsy: a prospective study. II. The EEG as predictor of outcome after withdrawal of treatment.

Author: AnderssonT, BraathenG, PerssonA, TheorellK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The presence of epileptiform activity does not necessarily influence prognosis after discontinuation of treatment, but certain types of such activity signal a high risk of relapse. Children with irregular generalized spike-wave activity in their last EEG recordings before discontinuation of treatment had a clearly higher relapse rate (67%) than children without epileptiform activity (33%) or with other types of epileptiform activity (33%).
Paper Details　
Original Abstract of the Article :
PURPOSE: We wished to evaluate the prognostic usefulness of various EEG parameters with respect to remission rates after discontinuation of antiepileptic drug (AED) therapy in children treated for epileptic seizures. METHODS: Two hundred forty-four children with uncomplicated epileptic seizures wer...See full text at original site
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引用元：
https://doi.org/10.1111/j.1528-1157.1997.tb01101.x

データ提供：米国国立医学図書館（NLM）

Childhood Epilepsy: Navigating the Desert of Treatment and Recovery

Epilepsy is a neurological disorder that can significantly impact a child's development and well-being. This study explores the prognostic value of various electroencephalogram (EEG) parameters in predicting relapse rates after antiepileptic drug (AED) treatment discontinuation in children with uncomplicated epileptic seizures. It's like exploring the complex terrain of a desert, seeking clues and patterns that can guide the journey toward successful recovery.

EEG as a Guidepost for Treatment Success

The study involved 244 children with uncomplicated epileptic seizures who were randomized to receive either one or three years of AED treatment. The researchers analyzed EEG recordings taken before, during, and after treatment, focusing on the presence and type of epileptiform activity. They found that the presence of irregular generalized spike-wave (SW) activity in the EEG recordings before treatment discontinuation was a strong predictor of relapse, suggesting that this type of activity may indicate a higher risk of seizures recurring. It's like discovering a particular type of sand dune that consistently signals the presence of a treacherous oasis in the desert, warning travelers to proceed with caution.

A Personalized Approach to Epilepsy Management

The study highlights the importance of individualized epilepsy management, taking into account the specific characteristics of each patient's EEG. It's a reminder that the desert of epilepsy treatment is vast and complex, and navigating this terrain requires careful observation and personalized strategies tailored to each individual's unique circumstances.

Dr.Camel's Conclusion

This study underscores the importance of EEG monitoring in predicting relapse rates after AED treatment discontinuation in children with epilepsy. It's a reminder that the journey toward successful epilepsy management requires vigilance, careful observation, and a personalized approach to treatment. By diligently monitoring EEG patterns and tailoring treatment strategies accordingly, we can navigate the challenges of epilepsy and create a more fulfilling life for those affected by this condition.

Date :
  1. Date Completed 1997-03-19
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

9048676

DOI: Digital Object Identifier

10.1111/j.1528-1157.1997.tb01101.x

SNS
PICO Info
in preparation
Languages

English

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