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Muscarinic m4 receptor activation by some atypical antipsychotic drugs.

Author: LeF, RichelsonE, ZengX P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Clozapine is an atypical neuroleptic that acts as both a muscarinic receptor agonist and antagonist. Clozapine showed a concentration-dependent and atropine-sensitive inhibition on cAMP formation, with EC50 = 60 nM and Emax = 74% of carbachol maximum. Muscarinic m4 receptor agonism may be a relevant mechanism for the therapeutic efficacy and side effects of clozapine.
Paper Details　
Original Abstract of the Article :
To clarify the findings that clozapine is both a muscarinic receptor agonist and antagonist, we examined the effects of neuroleptics on forskolin-stimulated cAMP accumulation in Chinese hamster ovary cells expressing human muscarinic m4 receptors (CHO-hm4) and in rat striatum. With CHO-hm4 cells, cl...See full text at original site
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引用元：
https://doi.org/10.1016/s0014-2999(96)00956-9

データ提供：米国国立医学図書館（NLM）

The Many Faces of Atypical Antipsychotic Drugs: Exploring Muscarinic m4 Receptor Activation

The human brain is a complex and mysterious organ, much like a vast desert with its own hidden secrets. Atypical antipsychotic drugs, used to treat mental health conditions, have a multifaceted impact on brain function, like the diverse plant life that thrives in a desert ecosystem. This study delves into the effects of these drugs on the muscarinic m4 receptor, a specific type of receptor found in the brain, much like studying the intricate interactions between different plant species in a desert environment.

A New Perspective on Atypical Antipsychotics

The researchers found that some atypical antipsychotics, including clozapine, fluperlapine, tenilapine, and olanzapine, activate the muscarinic m4 receptor, a finding that resembles discovering a unique type of desert plant with the ability to influence the ecosystem in unexpected ways. They also noted that this activation could contribute to both the therapeutic effects and side effects of these medications, highlighting the complex nature of their action.

Unveiling the Intricacies of Brain Function

This research offers valuable insights into the mechanisms of action of atypical antipsychotics, a group of medications often used to treat complex mental health conditions. The findings shed light on the intricate interplay between these drugs and the muscarinic m4 receptor, a key component of the brain's communication network.

Dr.Camel's Conclusion

This research, much like a journey into the heart of a desert, reveals the hidden complexities of brain function and the intricate relationships between atypical antipsychotic drugs and specific brain receptors. The findings offer a new perspective on the multifaceted nature of these medications, reminding us that even in the vast and mysterious landscape of the brain, there is always more to discover.

Date :
  1. Date Completed 1997-06-12
  2. Date Revised 2019-06-24
Further Info :

Pubmed ID

9085047

DOI: Digital Object Identifier

10.1016/s0014-2999(96)00956-9

SNS
PICO Info
in preparation
Languages

English

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