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Pharmacokinetics of estradiol and of estrone during application of three strengths of an estradiol transdermal patch with active matrix.

Author: GualanoV, GuillaumeM, MignotA, RenouxA, RovatiL C, SetnikarI, ThebaultJ J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A new transdermal estradiol patch with active matrix was well-tolerated and effective in increasing estradiol and estrone levels in women in menopause.
Paper Details　
Original Abstract of the Article :
The pharmacokinetic pattern of estradiol (CAS 50-28-2) and of estrone (CAS 53-16-7) during and after application of three strengths of a new transdermal estradiol patch (Dermestril) with active matrix was investigated in a cross-over study in 24 women in natural or surgical menopause. Free estradiol...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9272245

データ提供：米国国立医学図書館（NLM）

Estradiol Transdermal Patches: A Personalized Approach to Hormone Therapy

The quest for optimal hormone therapy continues to be a major focus in the field of women's health. This research investigates the pharmacokinetic profile of estradiol and estrone during the use of transdermal estradiol patches, offering a personalized approach to hormone replacement therapy. It's like carefully navigating the delicate balance of hormones in the body, seeking to achieve a state of equilibrium.

Tailored Hormone Delivery: A New Era of HRT

The study demonstrated that the new transdermal patches provide a controlled and predictable delivery of estradiol, achieving concentrations comparable to those observed during the early follicular phase in women of reproductive age. It's like finding a reliable oasis of hormone balance within the desert of hormonal fluctuations. This personalized approach to hormone therapy offers a more precise and potentially more effective way to manage hormone levels.

Personalized Hormone Replacement Therapy: A Better Way to Manage Menopause

This research highlights the potential of transdermal estradiol patches in providing a personalized and effective approach to hormone replacement therapy. It's like creating a custom-made desert oasis, tailored to the specific needs of each individual. By offering a controlled and predictable delivery of hormones, these patches could significantly improve the management of menopause and its associated symptoms.

Dr. Camel's Conclusion

This study delves into the world of estradiol transdermal patches, demonstrating their potential to revolutionize hormone replacement therapy. It's like finding a new oasis of hormone balance within the desert of menopause. These patches offer a more personalized and effective way to manage hormone levels, potentially improving the lives of women experiencing hormonal fluctuations.

Date :
  1. Date Completed 1997-10-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9272245

DOI: Digital Object Identifier

9272245

SNS
PICO Info
in preparation
Languages

English

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