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Treatment of first tonic-clonic seizure does not improve the prognosis of epilepsy. First Seizure Trial Group (FIRST Group).

Author: BeghiE, MusiccoM, SolariA, VianiF

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

In a study of 419 people who had a first seizure, those who started medication right away had a lower chance of having another seizure than those who waited for a second seizure to start treatment. However, the long-term chance of staying seizure-free was the same for both groups. Factors that predicted a higher risk of having another seizure included age, use of benzodiazepines during the initial seizure, and abnormal brain activity. The study suggests that medication can reduce the risk of having another seizure after a first seizure, but many people who are not treated will never have another seizure.
Paper Details　
Original Abstract of the Article :
It is widely agreed that after two or more seizures patients should be given antiepileptic treatment, but there is still controversy about the treatment of patients after a first unprovoked seizure. In a multicenter, randomized, open trial, patients with a first tonic-clonic seizure were randomized ...See full text at original site
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引用元：
https://doi.org/10.1212/wnl.49.4.991

データ提供：米国国立医学図書館（NLM）

The Complexities of Epilepsy: A Journey Through the Desert of Treatment Decisions

Epilepsy is a neurological disorder that affects millions worldwide. This research explores the controversial issue of treating patients who have experienced a first tonic-clonic seizure. It's like navigating a vast desert landscape, where the path to treatment is often unclear. The authors conducted a randomized, open trial to investigate the impact of immediate treatment versus delayed treatment for patients experiencing a first tonic-clonic seizure. Their findings indicate that anticonvulsants can reduce the risk of seizure recurrence, but they do not necessarily improve the long-term prognosis. The most notable finding is that 50% of patients who are not treated after a first seizure will never experience a second seizure.

Navigating the Uncertainties of Epilepsy Treatment

This research sheds light on the complexities of epilepsy treatment, highlighting the importance of individualized decision-making. The study's findings challenge the traditional approach of immediate treatment for all patients experiencing a first tonic-clonic seizure. It underscores the need for a careful evaluation of each patient's individual risk factors and the potential benefits and risks of treatment.

A Balanced Approach to Epilepsy Management

This research provides valuable insights into the evolving landscape of epilepsy treatment. It encourages a balanced approach, considering the individual needs of each patient and the potential benefits and risks of treatment. It is a reminder that the journey through the desert of epilepsy management often requires careful navigation and a willingness to adapt treatment strategies based on the specific circumstances of each patient.

Dr.Camel's Conclusion

The study of first tonic-clonic seizure treatment is like navigating a vast desert landscape, where the path to treatment is often unclear. This research provides valuable insights into the complexities of epilepsy management, emphasizing the importance of individualized decision-making, careful risk-benefit assessment, and a balanced approach to treatment.

Date :
  1. Date Completed 1997-11-14
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

9339678

DOI: Digital Object Identifier

10.1212/wnl.49.4.991

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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