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Effect of once daily and twice daily sustained release theophylline formulations on daytime variation of bronchial hyperresponsiveness in asthmatic patients.

Author: BiasinC, BonazzaL, FerrariM, LamprontiG, Lo CascioV, NacciP, OlivieriM, TalaminiG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

An ultrasustained release theophylline formulation administered once a day was more effective than a sustained release theophylline formulation administered twice a day in reducing bronchial responsiveness to methacholine in asthmatic patients.
Paper Details　
Original Abstract of the Article :
Previous studies evaluating spirometric values and symptoms have shown that once daily theophylline administered in the evening produces greater stabilisation of the airway function in asthmatic patients than the prototype theophylline given twice a day. The aim of this study was to compare the effe...See full text at original site
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引用元：
https://doi.org/10.1136/thx.52.11.969

データ提供：米国国立医学図書館（NLM）

Theophylline: Once Daily or Twice Daily?

This research examines the effects of different theophylline formulations on bronchial hyperresponsiveness in asthmatic patients. The study compared the effects of an ultrasustained release theophylline formulation (Diffumal-24) administered once a day, a sustained release theophylline formulation (Theo-Dur) administered twice a day, and placebo. The primary outcome was the variation in bronchial responsiveness to methacholine. While previous research has shown that once-daily evening administration of theophylline can stabilize airway function, this study sought to explore the nuances of different formulations and administration schedules.

Theophylline's Effectiveness in Different Formulations

The study aimed to compare the effects of different theophylline formulations on bronchial hyperresponsiveness in asthmatic patients. While the study design and specific findings are not detailed here, it is clear that researchers aimed to understand the optimal theophylline formulation and dosage schedule for managing asthma.

Asthma Management: A Personalized Approach

This study, like a desert wind that shifts the sands, emphasizes the importance of personalized asthma management. It highlights the fact that different theophylline formulations and administration schedules can have varying effects on bronchial hyperresponsiveness. Consulting with your doctor and understanding the specific needs of your condition is crucial for optimizing asthma management and achieving optimal relief.

Dr.Camel's Conclusion

This study is like a desert explorer carefully charting a path through a vast, unknown landscape. Researchers are meticulously investigating the nuances of theophylline formulations and their impact on asthma. This exploration is essential to understand the best ways to utilize this medication for individuals with asthma, ensuring the most effective treatment plan for each person's unique needs.

Date :
  1. Date Completed 1998-03-06
  2. Date Revised 2019-05-03
Further Info :

Pubmed ID

9487345

DOI: Digital Object Identifier

10.1136/thx.52.11.969

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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