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Amlodipine in patients with stable angina pectoris treated with beta-blockers. Double-blind comparison with placebo.

Author: NieminenM S, PartanenJ, RossinenJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Amlodipine (AML) did not significantly improve anti-ischemic effects on coronary artery disease (CAD) patients already treated with beta-blockers. Blood pressure was reduced by AML and the total variability and very low frequency component of heart rate were reduced.
Paper Details　
Original Abstract of the Article :
In order to assess additional anti-ischaemic effects of amlodipine (AML) on coronary artery disease (CAD) treated with beta-blockers, 32 patients with CAD, verified on angiograms, and stable angina were randomized to receive 5 mg/day of AML or placebo, increasing to 10 mg/day after 2 weeks. Baseline...See full text at original site
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引用元：
https://doi.org/10.1080/14017439850140337

データ提供：米国国立医学図書館（NLM）

Amlodipine in Stable Angina Pectoris: A Double-Blind Study

Stable angina pectoris is a common cardiovascular condition characterized by chest pain caused by reduced blood flow to the heart. This study investigates the additional anti-ischaemic effects of amlodipine, a calcium channel blocker, in patients with stable angina who are already taking beta-blockers. The study was a double-blind randomized trial that compared amlodipine to placebo. The researchers found that amlodipine did not significantly reduce ambulatory ischemia or improve exercise tolerance. However, amlodipine did reduce blood pressure and altered heart rate variability.

A Complex Landscape: Amlodipine and Stable Angina

Think of the cardiovascular system as a vast desert landscape, where blood vessels meander through a complex network. Amlodipine, like a careful irrigation system, can help to improve blood flow and alleviate chest pain. This study reveals the intricate interplay between amlodipine and beta-blockers, suggesting that the combined effects of these medications may not always be predictable. It highlights the importance of individualized treatment approaches for patients with stable angina.

Understanding the Effects of Amlodipine

This study provides valuable information for clinicians treating patients with stable angina. It suggests that amlodipine may not provide significant additional benefits in patients already taking beta-blockers. However, it also highlights the potential impact of amlodipine on blood pressure and heart rate variability, factors that may need to be carefully considered when prescribing this medication.

Dr. Camel's Conclusion

This research explores the complexities of treating stable angina with amlodipine, highlighting the need for careful consideration of individual patient characteristics and potential drug interactions. Much like a camel navigating a desert landscape, clinicians must be aware of the potential pitfalls and navigate the path to treatment with a keen eye and a deep understanding of the terrain.
Date :
  1. Date Completed 1998-05-19
  2. Date Revised 2019-11-02
Further Info :

Pubmed ID

9536505

DOI: Digital Object Identifier

10.1080/14017439850140337

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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