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The airway effects of stopping regular oral theophylline in patients with asthma.

Author: BennettJ A, PavordI D, TattersfieldA E, Thompson CoonJ, WildingP J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Cessation of theophylline therapy can lead to a small rebound deterioration in lung function, consistent with the development of tolerance.
Paper Details　
Original Abstract of the Article :
AIMS: We investigated whether the deterioration in asthma control reported following cessation of theophylline was due to tolerance to theophylline. METHODS: Eighteen subjects with mild stable asthma were given oral theophylline 10 mg kg(-1) day(-1) or placebo for 2 weeks in a double-blind crossove...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2125.1998.t01-1-00691.x

データ提供：米国国立医学図書館（NLM）

Theophylline: A Desert Oasis with a Twist

Asthma, like a desert mirage, can be a persistent and unpredictable condition. This [double-blind crossover study] investigates the effects of stopping regular theophylline treatment, a common asthma medication, on lung function. The researchers found that while theophylline was well-tolerated and improved lung function during treatment, a slight decline in lung function was observed after stopping the medication. This is like a desert oasis that gradually dries up: theophylline provides temporary relief, but withdrawal can lead to a rebound effect.

Tolerance and Rebound: Navigating the Desert of Asthma

The study highlights the potential for tolerance to theophylline, a phenomenon where the body becomes less responsive to the medication over time. This can lead to a rebound in asthma symptoms when the medication is stopped.

Managing Asthma Effectively

The study suggests that careful monitoring and individualised treatment plans are essential for managing asthma. This includes considering the potential for tolerance and adjusting medication regimens accordingly.

Dr.Camel's Conclusion

Theophylline can be a valuable tool for managing asthma, but understanding the potential for tolerance and rebound is crucial for achieving optimal treatment outcomes. It's like navigating a desert: you need to be aware of the shifting sands and adapt your journey accordingly.

Date :
  1. Date Completed 1998-06-08
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

9578190

DOI: Digital Object Identifier

10.1046/j.1365-2125.1998.t01-1-00691.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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