Paper Details

  1. Home
  2. Paper Details

Eradication of Helicobacter pylori with lansoprazole, roxithromycin and metronidazole--an open pilot study.

Author: BockH, DomschkeW, HeepM, KirchnerT, LehnN, PohleT, StollR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The combination of lansoprazole, roxithromycin and metronidazole proved to be as safe as other current triple therapy regimens. In a study of 163 patients with duodenal ulcer and proven H. pylori infection, H. pylori was successfully eradicated in 84.7% of cases as determined by urease quick test, 78.0% by histology, 81.3% by 13C-urea breath test; and in 75.3%, at least two tests were negative.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The most extensively studied Helicobacter pylori eradication regimen comprises omeprazole, clarithromycin and metronidazole. Macrolide antibiotics other than clarithromycin should achieve similar efficacy, but they have not yet been thoroughly tested. AIM: To determine the efficacy and ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1046/j.1365-2036.1998.00433.x

データ提供：米国国立医学図書館（NLM）

Eradication of Helicobacter pylori with Lansoprazole, Roxithromycin and Metronidazole

The fight against [Helicobacter pylori (H. pylori)] infection is a battle that requires a strong strategy. This study explores the efficacy of a new triple therapy regimen using [lansoprazole, roxithromycin, and metronidazole] to eradicate this bacteria. It's like finding a new weapon in the desert arsenal, one that can combat a stubborn foe.

The researchers conducted an [open pilot study] involving [163 patients] with [duodenal ulcer and proven H. pylori infection]. They found that [the regimen successfully eradicated H. pylori in 84.7% of patients], suggesting its potential as a viable treatment option. It's like finding a new oasis with a different type of water source – a fresh perspective on tackling a persistent problem.

The Promise of a New Treatment Regimen

The study suggests that [lansoprazole, roxithromycin, and metronidazole] could be an effective alternative to existing triple therapy regimens for [H. pylori eradication]. This discovery offers a potential solution to the challenges posed by [antibiotic resistance], similar to finding a new water source in a desert with dwindling resources.

The Importance of Continued Research

The study highlights the need for further research to confirm the efficacy and safety of this [new treatment regimen]. It's like testing the water quality of a newly discovered oasis – ensuring its suitability for long-term use.

Dr.Camel's Conclusion

This research offers a glimmer of hope in the fight against [H. pylori infections]. By exploring new treatment options, we can continue to develop effective strategies for combating this persistent foe. It's like finding a new pathway through the desert, leading us closer to a solution.

Date :
  1. Date Completed 1999-04-21
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

9882038

DOI: Digital Object Identifier

10.1046/j.1365-2036.1998.00433.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.