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The effect of anastrozole on the pharmacokinetics of tamoxifen in post-menopausal women with early breast cancer.

Author: BaumM, BlackmanG M, DowsettM, HowellA, KingN, PonzoneR, TobiasJ S, WelchH, von EulerM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Anastrozole, an aromatase inhibitor, did not affect the pharmacokinetics of tamoxifen when given together to postmenopausal women with breast cancer. Anastrozole remained effective in suppressing oestradiol levels even in the presence of tamoxifen.
Paper Details　
Original Abstract of the Article :
Thirty-four post-menopausal women with early breast cancer who had received 20 mg tamoxifen once daily as adjuvant therapy for at least 10 weeks participated in a randomized, double-blind, parallel-group, multicentre trial. The primary aim of the trial was to determine the effect of anastrozole upon...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362190/

データ提供：米国国立医学図書館（NLM）

Anastrozole and Tamoxifen: A Camel's View of Breast Cancer Treatment

The world of breast cancer treatment is a complex desert, with researchers constantly searching for the most effective therapies. This research explores the interplay between two medications, anastrozole and tamoxifen, used in the treatment of post-menopausal women with early breast cancer. It's like exploring the intricacies of a vast sand dune system, seeking to understand the interactions between different elements.

The study found that anastrozole did not affect the pharmacokinetics of tamoxifen when the two drugs were given in combination. This is like discovering that two separate desert oases can coexist harmoniously, each contributing to the overall well-being of the ecosystem.

Harmonious Coexistence in Breast Cancer Treatment

The findings are encouraging, suggesting that anastrozole and tamoxifen can be safely and effectively combined to enhance treatment outcomes. This is like finding a new path through the desert, allowing for a smoother and more effective journey towards recovery.

A Camel's Guide to Breast Cancer Treatment

If you're undergoing treatment for breast cancer, it's important to discuss the potential benefits and risks of different medications with your doctor. It's like consulting a wise camel guide, ensuring a safe and effective journey through the desert of treatment.

Dr. Camel's Conclusion

This research is a testament to the power of scientific collaboration. It's like discovering that two separate oases can work together to create a more flourishing ecosystem. This knowledge is invaluable for patients facing the challenges of breast cancer.

Date :
  1. Date Completed 1999-01-19
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

9888474

DOI: Digital Object Identifier

PMC2362190

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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