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Fluticasone propionate powder: oral corticosteroid-sparing effect and improved lung function and quality of life in patients with severe chronic asthma.

Author: BergerW E, BusseW W, HamedaniA G, HardingS M, MahajanP S, NelsonH S, NoonanM J, ShahT, WebbD R, WolfordJ P, deBoisblancB P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Fluticasone propionate powder (500 or 1000 microg twice daily) effectively improved lung function, adrenal function, and asthma-specific quality of life in patients with severe chronic asthma previously treated with oral prednisone while allowing most patients to be weaned off oral corticosteroid therapy. In a study of 111 patients with severe chronic asthma, oral prednisone was eliminated by 75% and 89% of patients in the twice daily 500 and 1000 microg fluticasone propionate groups, respectively, versus 9% of the placebo group.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Many patients with severe asthma are dependent on oral corticosteroids for maintenance control of their disease. Treatments that allow patients to be weaned off oral corticosteroids may help to minimize the risk of side effects associated with their chronic use. OBJECTIVE: This study ev...See full text at original site
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引用元：
https://doi.org/10.1016/s0091-6749(99)70501-4

データ提供：米国国立医学図書館（NLM）

Fluticasone Propionate: A Breath of Fresh Air for Asthma Sufferers

The field of respiratory medicine is constantly seeking new and effective treatments for asthma, a condition that affects millions worldwide. This study investigated the efficacy of inhaled fluticasone propionate powder in reducing the dependence on oral corticosteroids in patients with severe chronic asthma. The researchers conducted a double-blind, parallel-group study, comparing fluticasone propionate to a placebo. Their findings demonstrate the potential of this inhaled corticosteroid to improve lung function, reduce oral corticosteroid dependence, and enhance quality of life for patients with severe asthma.

Fluticasone Propionate: A Powerful Tool for Asthma Management

The research found that fluticasone propionate powder was effective in reducing oral corticosteroid dependence and improving lung function in patients with severe chronic asthma. This finding offers a valuable alternative for patients seeking to minimize the side effects associated with long-term oral corticosteroid use, allowing them to breathe easier and live a more comfortable life.

Improving Asthma Management and Quality of Life

The study demonstrates the significant benefits of fluticasone propionate for managing asthma. By reducing oral corticosteroid dependence, this medication not only improves lung function but also enhances quality of life. This is particularly important for patients with severe asthma, who often face significant limitations in their daily activities. Much like finding a cool oasis in a scorching desert, this research points the way towards better asthma management and a more fulfilling life for those who struggle with this condition.

Dr.Camel's Conclusion

Asthma, like a desert wind, can be unpredictable and uncomfortable. This research provides a ray of hope for patients struggling with severe chronic asthma. Fluticasone propionate powder, like a refreshing breeze in the desert, offers a potential solution for reducing oral corticosteroid dependence and improving quality of life. With this knowledge, we can continue to find ways to navigate the challenges of asthma and create a more comfortable and fulfilling life for those who live with this condition.

Date :
  1. Date Completed 1999-03-11
  2. Date Revised 2019-07-23
Further Info :

Pubmed ID

9949318

DOI: Digital Object Identifier

10.1016/s0091-6749(99)70501-4

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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