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[Inhibition of HCFU absorption after resection for gastric cancer--application of hydroxyaluminium gel].

Author: KageyamaT, TamuraY, ToizumiA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effect of co-administering hydroxyaluminium gel (ALG) with HCFU, a 5-FU analog, on the concentration of HCFU and 5-FU in blood after gastric resection. The results suggest that co-administration of HCFU with ALG may be effective in inhibiting adverse drug reactions after gastric cancer resection.
Paper Details　
Original Abstract of the Article :
HCFU (carmofur; Mifurol) is an 5-FU analog. The maximum blood concentration of HCFU in HCFU fraction (Cmax) after gastric resection was higher than before resection. Hot sensation and pollakiuria, characteristic side effects of HCFU, are dependent on concentration of HCFU fraction in blood. Therefor...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11432348

データ提供：米国国立医学図書館（NLM）

Inhibition of HCFU Absorption: A Strategy for Managing Side Effects

This study explores the potential of hydroxyaluminium gel (ALG) to reduce the absorption of HCFU (carmofur; Mifurol), a 5-FU analog, after gastric resection. The authors highlight the challenge of managing side effects associated with HCFU, such as hot sensation and pollakiuria, which are often exacerbated after gastric resection due to increased HCFU absorption.

Hydroxyaluminium Gel: A Potential Absorption Inhibitor

The study investigated the effects of co-administering HCFU with ALG in patients who had undergone gastric resection. The results suggest that ALG may indeed decrease HCFU absorption, as the concentration of HCFU in the HCFU fraction was significantly lower in patients who received ALG compared to those who received HCFU alone. This finding suggests that ALG could potentially reduce the incidence of HCFU-related side effects after gastric resection.

Managing Side Effects: Balancing Benefits and Risks

While the study demonstrates the potential of ALG to reduce HCFU absorption, further research is needed to fully evaluate its efficacy and safety. It is crucial to weigh the potential benefits of reducing HCFU-related side effects against any potential risks associated with ALG. A thorough understanding of the pharmacokinetic interactions between HCFU and ALG is essential for developing safe and effective treatment strategies.

Dr. Camel's Conclusion

Side effects from medications can sometimes feel like a desert mirage, offering temporary relief but potentially leading to discomfort. This study explores a potential solution to manage side effects associated with HCFU, but further exploration is needed to ensure its safety and effectiveness.

Date :
  1. Date Completed 2001-07-19
  2. Date Revised 2021-08-26
Further Info :

Pubmed ID

11432348

DOI: Digital Object Identifier

11432348

SNS
PICO Info
in preparation
Languages

Japanese

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