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Efficacy and tolerability of controlled-release and immediate-release paroxetine in the treatment of depression.

Author: DubéEric M, GoldenRobert N, McSorleyPaul, NemeroffCharles B, PittsCornelius D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Paroxetine controlled-release (CR) has been developed to improve general tolerability, particularly gastrointestinal tolerability, in patients taking antidepressants.
Paper Details　
Original Abstract of the Article :
Antidepressant efficacy may be compromised by early discontinuation of treatment secondary to common, treatment-emergent side effects, including nausea, agitation, and somnolence. Paroxetine controlled-release (CR) was developed to improve general tolerability and, in particular, gastrointestinal to...See full text at original site
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引用元：
https://doi.org/10.4088/jcp.v63n0707

データ提供：米国国立医学図書館（NLM）

Paroxetine: A New Route Through the Desert of Depression

Depression can be a challenging experience, and finding the right medication can feel like navigating a vast desert. This research explores the efficacy and tolerability of controlled-release paroxetine, a new formulation of this antidepressant medication. It's like a scientific expedition searching for a more effective and comfortable way to travel through the desert of depression.

Easing the Journey: Controlled-Release Paroxetine Shows Promise

The study's findings are like discovering a hidden oasis in the desert of depression. Controlled-release paroxetine demonstrated comparable efficacy to immediate-release paroxetine in treating depression. Importantly, it also showed a more favorable tolerability profile, with fewer side effects, especially gastrointestinal discomfort. This discovery could represent a significant improvement in the treatment of depression, offering a potentially more comfortable and effective therapeutic option.

Finding the Right Path: Choosing the Best Treatment for You

The desert of depression can be vast and confusing, with many different paths to consider. This study highlights the importance of choosing the right treatment, taking into account individual needs and preferences. Understanding the potential benefits and risks of different medications can help us make more informed decisions about our treatment options. It's like having a reliable guide to help us navigate the desert and find the best path to recovery.

Dr. Camel's Conclusion

This research is like a compass, guiding us through the diverse landscape of antidepressant therapies. The emergence of controlled-release paroxetine offers a potentially more comfortable and effective option for treating depression. The study underscores the importance of choosing the right treatment for each individual and highlights the ongoing quest for safer and more effective therapies for this prevalent condition.

Date :
  1. Date Completed 2002-08-08
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

12143913

DOI: Digital Object Identifier

10.4088/jcp.v63n0707

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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